Drugs / Murepavadin
last change Jul 2019 re-read 2 minutes ago

Murepavadin

also known as POL7080 · RO7033877 · Murepavadina · Murepavadine

Peptide

Developed for
pneumonia · respiratory tract infectious disorder · bronchiectasis
Investigated by
Polyphor Ltd. · Hoffmann-La Roche

Trials 9 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 15 trials
Phase 1 NCT02897869 Apr → Aug 2016 Polyphor Ltd. Completed No outcome recorded
Phase 1 NCT02165332 Jul → Nov 2014 Hoffmann-La Roche Completed No outcome recorded
Phase 1 NCT02156323 Jul 2014 → Mar 2015 Hoffmann-La Roche Completed No outcome recorded
Phase 1 NCT02165293 Jun → Sep 2014 Hoffmann-La Roche Completed No outcome recorded
Phase 1 NCT02110459 Apr 2013 → Jul 2015 impaired renal function disease Polyphor Ltd. Completed No outcome recorded
Phase 22 trials
Phase 2 NCT02096315 Dec 2013 → Nov 2015 bronchiectasis, respiratory tract infectious disorder Polyphor Ltd. Terminated No outcome recorded
Phase 2 NCT02096328 Oct 2013 → Dec 2015 respiratory tract infectious disorder Polyphor Ltd. Completed No outcome recorded
Phase 32 trials
Phase 3 NCT03582007 Oct 2018 → Jul 2019 pneumonia Polyphor Ltd. Terminated No outcome recorded
Phase 3 NCT03409679 Mar 2018 → Jul 2019 pneumonia Polyphor Ltd. Terminated No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 10 sources stand behind the page.

FieldValueCited text
Known as Murepavadin “Pharmacokinetics, Tolerability, and Safety of Murepavadin, a Novel Antipseudomonal Antibiotic, in Subjects with Mild, Moderate, or Severe Renal Function Impairment.” PMID 30012756 Aug 2018
2

NCT03582007

NCT03409679

Known as Murepavadina ChEMBL registry synonym — accepted as the source's own label CHEMBL3946483
Known as Murepavadine ChEMBL registry synonym — accepted as the source's own label CHEMBL3946483
Known as POL7080 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02096315
2

NCT02897869

NCT02096328

Known as RO7033877 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02165293
2

NCT02156323

NCT02165332

Modality Peptide “a novel peptide antibiotic” PMID 30012756 Aug 2018
Route Intravenous Intravenous infusion” NCT02096315