Drugs / MIGOPROTAFIB
last change Sep 2025 re-read 2 minutes ago

MIGOPROTAFIB

also known as GDC-1971 · RG-6433 · RLY-1971 · RO-7517834 · RTX-1084260

Small molecule

Developed for
cancer · colorectal cancer · non-small cell lung carcinoma · metastatic neoplasm
Investigated by
Genentech, Inc. · Hoffmann-La Roche

Trials 4 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT05954871 Jan 2024 → Sep 2025 colorectal cancer, non-small cell lung carcinoma Genentech, Inc. Completed No outcome recorded
Phase 1 NCT05487235 Aug 2022 → Jun 2025 cancer, metastatic neoplasm Genentech, Inc. Completed No outcome recorded
Phase 1 NCT04449874 Jul 2020 → Dec 2027 expected colorectal cancer, non-small cell lung carcinoma Genentech, Inc. Active not recruiting No outcome recorded
Phase 1 NCT04252339 Feb 2020 → Nov 2022 cancer Hoffmann-La Roche Completed No outcome recorded

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as MIGOPROTAFIB ChEMBL registry synonym — accepted as the source's own label CHEMBL5314471
Known as GDC-1971 ClinicalTrials.gov intervention name — accepted as the source's own label NCT04449874
2

NCT05487235

NCT05954871

Known as RG-6433 ChEMBL registry synonym — accepted as the source's own label CHEMBL5314471
Known as RLY-1971 ClinicalTrials.gov intervention name — accepted as the source's own label NCT04252339
Known as RO-7517834 ChEMBL registry synonym — accepted as the source's own label CHEMBL5314471
Known as RTX-1084260 ChEMBL registry synonym — accepted as the source's own label CHEMBL5314471
Action Inhibit “RLY-1971 is an oral inhibitor of SHP2.” NCT04252339
Modality Small molecule CHEMBL5314471
Route Oral “RLY-1971 is an oral inhibitor of SHP2.” NCT04252339