Drugs / diphenoxylate
diphenoxylate
also known as
Difenoxilato · Diphenoxylate HCL · DIPHENOXYLATE HYDROCHLORIDE · Diphenoxylate hydrochloride cii · Diphenoxylate hydrochloride component of colonaid · Diphenoxylate hydrochloride component of di-atro · Diphenoxylate hydrochloride component of lo-trol · Diphenoxylate hydrochloride component of logen · +7 more
Small molecule targets OPRM1 via activation
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | LOMOTIL | — | 1960-09-15 | fda.gov ↗ |
Trials 1
1959196019611962196319641965196619671968196919701971197219731974197519761977197819791980198119821983198419851986198719881989199019911992199319941995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 31 trial | ||||||
| Phase 3 | NCT00583323 | Feb 2003 → Sep 2005 | lymphoma | Mayo Clinic | Completed | No outcome recorded |
| Comparator or background therapy1 trial | ||||||
| Phase 1/2 | NCT02858310 Background | Jan 2017 → Jul 2025 | cervical intraepithelial neoplasia, human papilloma virus infection, in situ carcinoma, vulvar neoplasm | National Cancer Institute (NCI) | Completed | No outcome recorded |
Evidence & citations 19 cited values
Every value below carries the sentence it was read from. 3 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | diphenoxylate | “diphenoxylate/atropine 5mg/0.05mg (Lomotil) decreases bowel activity” NCT00583323 ↗ |
| Known as | Difenoxilato | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201294 ↗ |
| Known as | Diphenoxylate HCL | ClinicalTrials.gov intervention name — accepted as the source's own label NCT02858310 ↗ |
| Known as | DIPHENOXYLATE HYDROCHLORIDE | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201294 ↗ |
| Known as | Diphenoxylate hydrochloride cii | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201294 ↗ |
| Known as | Diphenoxylate hydrochloride component of colonaid | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201294 ↗ |
| Known as | Diphenoxylate hydrochloride component of di-atro | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201294 ↗ |
| Known as | Diphenoxylate hydrochloride component of lo-trol | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201294 ↗ |
| Known as | Diphenoxylate hydrochloride component of logen | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201294 ↗ |
| Known as | Diphenoxylate hydrochloride component of lomanate | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201294 ↗ |
| Known as | Diphenoxylate hydrochloride component of lomotil | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201294 ↗ |
| Known as | Diphenoxylate hydrochloride component of lonox | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201294 ↗ |
| Known as | Diphenoxylate hydrochloride component of low-quel | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201294 ↗ |
| Known as | Diphenoxylati hydrochloridum | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201294 ↗ |
| Known as | IDS-ND-016 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201294 ↗ |
| Known as | R-1132 (ANTIPERISTALTIC) | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201294 ↗ |
| Action | Activate | “Mu opioid receptor agonist” CHEMBL1201294 ↗ |
| Modality | Small molecule | — CHEMBL1201294 ↗ |
| Target | OPRM1 | “Mu opioid receptor agonist” CHEMBL1201294 ↗ |