Drugs / Tibulizumab
last change May 2025 re-read 3 minutes ago

Tibulizumab

also known as LY3090106

Monoclonal antibody targets IL17A, TNFSF13B via inhibition

Developed for
Sjogren syndrome · hidradenitis suppurativa · rheumatoid arthritis · systemic sclerosis
Investigated by
Eli Lilly and Company · Zura Bio Inc · Matthew C. Baker

Trials 6

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT03736772 Nov 2018 → Mar 2019 — Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT02614716 Dec 2015 → Sep 2018 Sjogren syndrome Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01925157 Aug 2013 → Jan 2015 rheumatoid arthritis Eli Lilly and Company Completed No outcome recorded
Phase 22 trials
Phase 2 NCT06993610 May 2025 → Nov 2026 expected hidradenitis suppurativa Zura Bio Inc Active not recruiting No outcome recorded
Phase 2 NCT06843239 Feb 2025 → May 2027 expected systemic sclerosis Zura Bio Inc Active not recruiting No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT04563195 Feb 2022 → Dec 2023 Sjogren syndrome Matthew C. Baker Withdrawn No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 7 sources stand behind the page.

FieldValueCited text
Known as Tibulizumab ClinicalTrials.gov intervention name — accepted as the source's own label NCT06843239 ↗
2

NCT04563195 ↗

NCT06993610 ↗

Known as LY3090106 “To demonstrate that tibulizumab (LY3090106) treatment improves the mean unstimulated salivary flow rate or the salivary gland total ultrasound score (TUS) in primary Sjogren's...” NCT04563195 ↗
3

NCT01925157 ↗

NCT02614716 ↗

NCT03736772 ↗

Action Inhibit “Tumor necrosis factor ligand superfamily member 13B inhibitor” CHEMBL3990000 ↗
2

“Interleukin 17A inhibitor” CHEMBL3990000 ↗

“Anti BAFF/IL-17 antibody.” NCT06993610 ↗

Modality Monoclonal antibody — CHEMBL3990000 ↗
Route Subcutaneous “Administered SQ.” NCT01925157 ↗
Target IL17A “Interleukin 17A inhibitor” CHEMBL3990000 ↗
Target TNFSF13B “Tumor necrosis factor ligand superfamily member 13B inhibitor” CHEMBL3990000 ↗