Drugs / Lecozotan
last change Sep 2008 re-read 2 minutes ago

Lecozotan

Small molecule targets HTR1A via inhibition

Developed for
Alzheimer disease
Investigated by
Wyeth is now a wholly owned subsidiary of Pfizer · Pfizer

Trials 8 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 15 trials
Phase 1 NCT00563732 Dec 2007 → Sep 2008 Alzheimer disease Wyeth is now a wholly owned subsidiary of Pfizer Completed No outcome recorded
Phase 1 NCT00538889 Aug → Nov 2007 Wyeth is now a wholly owned subsidiary of Pfizer Completed No outcome recorded
Phase 1 NCT00494962 Jun 2007 Alzheimer disease Wyeth is now a wholly owned subsidiary of Pfizer Completed No outcome recorded
Phase 1 NCT00499642 Jun → Aug 2007 Alzheimer disease Wyeth is now a wholly owned subsidiary of Pfizer Completed No outcome recorded
Phase 1 NCT00366483 May 2006 → ? Alzheimer disease Wyeth is now a wholly owned subsidiary of Pfizer Completed No outcome recorded
Phase 22 trials
Phase 2 NCT00151398 Oct 2005 → Mar 2008 Alzheimer disease Wyeth is now a wholly owned subsidiary of Pfizer Completed No outcome recorded
Phase 2 NCT00151333 Feb → Apr 2005 Alzheimer disease Wyeth is now a wholly owned subsidiary of Pfizer Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT00277810 Mar 2006 → Jun 2008 Alzheimer disease Pfizer Completed No outcome recorded

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 9 sources stand behind the page.

FieldValueCited text
Known as Lecozotan ClinicalTrials.gov intervention name — accepted as the source's own label NCT00538889
6

NCT00494962

NCT00277810

NCT00499642

NCT00563732

NCT00151398

NCT00366483

Known as Lecozotan hcl ChEMBL registry synonym — accepted as the source's own label CHEMBL372205
Known as LECOZOTAN HYDROCHLORIDE ChEMBL registry synonym — accepted as the source's own label CHEMBL372205
Known as lecozotan SR “Drug: lecozotan SRNCT00151398
Known as SRA-333 “A 3-Month, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Safety, Tolerability, and Efficacy Study Of 3 Doses Of Lecozotan (SRA-333) SR In Outpatients With Mild To...” NCT00151398
2

“lecozotan SR (SRA-333)” NCT00277810

NCT00151333

Action Inhibit “Serotonin 1a (5-HT1a) receptor antagonist” CHEMBL372205
Modality Small molecule CHEMBL372205
Route Oral “Administered Orally” NCT00366483
Target HTR1A “Serotonin 1a (5-HT1a) receptor antagonist” CHEMBL372205