Drugs / Diacerein
last change Jun 2026 re-read 2 minutes ago

Diacerein

also known as AC-201 · AC-203 · AC-201 CR tablet · Artrodar · DAR · Diacerhein

Small molecule targets IL1B, JAK1, TYK2 via inhibition

Developed for
osteoarthritis, knee · epidermolysis bullosa simplex · type 2 diabetes mellitus · gout · psoriasis · bullous pemphigoid · hemophilic arthropathy · hyperglycemia
+11 more · inherited epidermolysis bullosa · metabolic dysfunction-associated steatotic liver disease · NAFLD1 · obesity disorder · osteoarthritis · osteoarthritis, hand · osteoarthritis, hip · primary thrombocytopenia · rheumatoid arthritis · thrombocytopenia · COVID-19
Investigated by
Castle Creek Pharmaceuticals, LLC · TWi Biotechnology, Inc. · Laboratoires NEGMA · TRB Chemedica · Accro Bioscience (Suzhou) Limited · Anhui Medical University
+24 more · ArthroLab Inc. · Cairo University · Coordinación de Investigación en Salud, Mexico · Federal University of Rio de Janeiro · Government Medical College, Amritsar · Hongyan Wu · Indonesia Endowment Fund for Education (LPDP), Ministry of Finance Republik of Indonesia · Korea University Guro Hospital · Myungmoon Pharm. Co. · National Council of Science and Technology, Mexico · Qilu Hospital of Shandong University · Ramathibodi Hospital · Rio de Janeiro State Research Supporting Foundation (FAPERJ) · Seoul National University Hospital · Shandong University · Shenzhen Second People's Hospital · TKL Research, Inc. · TRB Chemedica International SA · The Affiliated Hospital of the Chinese Academy of Military Medical Sciences · The First Affiliated Hospital of Dalian Medical University · Tongji Hospital · Universitas Sriwijaya · Whan-Seok Choi · Zhejiang Provincial Hospital of TCM

Trials 33 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 15 trials
Phase 1 NCT03472287 May 2018 → Jan 2019 epidermolysis bullosa dystrophica, epidermolysis bullosa simplex, junctional epidermolysis bullosa Castle Creek Pharmaceuticals, LLC Completed No outcome recorded
Phase 1 NCT03472547 Jan → Mar 2018 Castle Creek Pharmaceuticals, LLC Completed No outcome recorded
Phase 1 NCT03472534 Jan 2018 Castle Creek Pharmaceuticals, LLC Completed No outcome recorded
Phase 1 NCT03473197 Jan → Mar 2018 Castle Creek Pharmaceuticals, LLC Completed No outcome recorded
Phase 1 NCT03473184 Dec 2017 Castle Creek Pharmaceuticals, LLC Completed No outcome recorded
Phase 213 trials
Phase 2 NCT06972888 Apr 2024 → Mar 2025 psoriasis Accro Bioscience (Suzhou) Limited Completed No outcome recorded
Phase 2 NCT04917679 Sep 2020 → Dec 2021 primary thrombocytopenia Qilu Hospital of Shandong University Completed No outcome recorded
Phase 2 NCT03754634 May 2019 → Jun 2020 thrombocytopenia Shandong University Completed No outcome recorded
Phase 2 NCT03468322 Oct 2018 → Apr 2019 inherited epidermolysis bullosa TWi Biotechnology, Inc. Completed No outcome recorded
Phase 2 NCT03389308 Dec 2017 → Apr 2020 epidermolysis bullosa simplex Castle Creek Pharmaceuticals, LLC Completed No outcome recorded
Phase 2 NCT03286582 Sep 2017 → Dec 2018 bullous pemphigoid TWi Biotechnology, Inc. Terminated No outcome recorded
Phase 2 NCT03154333 Jun 2017 → Oct 2018 epidermolysis bullosa simplex Castle Creek Pharmaceuticals, LLC Terminated No outcome recorded
Phase 2 NCT02994147 Mar 2017 → Apr 2019 hemophilic arthropathy TWi Biotechnology, Inc. Completed No outcome recorded
Phase 2 NCT02287818 Dec 2014 → Oct 2016 gout TWi Biotechnology, Inc. Completed No outcome recorded
Phase 2 NCT01712204 Jan → Sep 2013 gout TWi Biotechnology, Inc. Completed No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT06912035 Jun → Nov 2024 hyperglycemia, type 2 diabetes mellitus Universitas Sriwijaya Completed No outcome recorded
Phase 2/3 NCT06073132 Apr 2024 → Jun 2026 overdue epidermolysis bullosa simplex TWi Biotechnology, Inc. Active not recruiting No outcome recorded
Phase 34 trials
Phase 3 NCT04318041 Nov 2020 → Dec 2026 expected osteoarthritis, knee TRB Chemedica Recruiting No outcome recorded
Phase 3 NCT02688400 May 2016 → Jun 2018 osteoarthritis, knee TRB Chemedica International SA Completed No outcome recorded
Phase 3 NCT02242149 Oct 2014 → Jan 2017 NAFLD1, type 2 diabetes mellitus Federal University of Rio de Janeiro Completed No outcome recorded
Phase 3 NCT00451360 Mar 1993 → Apr 1997 osteoarthritis, hip Laboratoires NEGMA Completed No outcome recorded
Phase 48 trials
Phase 4 NCT07352306 Feb 2026 → Feb 2027 expected psoriasis Cairo University Not yet recruiting No outcome recorded
Phase 4 NCT03404479 Jan 2018 → Jan 2019 osteoarthritis, knee Whan-Seok Choi Unknown No outcome recorded
Phase 4 NCT01906801 Jul 2013 → Oct 2014 osteoarthritis, knee Ramathibodi Hospital Completed No outcome recorded
Phase 4 NCT02060552 Jan 2013 → Mar 2014 gout Tongji Hospital Completed No outcome recorded
Phase 4 NCT00685542 Jun 2008 → Oct 2009 osteoarthritis, hand Seoul National University Hospital Completed No outcome recorded
Phase 4 NCT00440661 Mar 2007 → Oct 2008 osteoarthritis Laboratoires NEGMA Completed No outcome recorded
Phase 4 NCT01120015 Jan 2007 → Jun 2008 osteoarthritis, knee Government Medical College, Amritsar Completed No outcome recorded
Phase 4 NCT00445276 Nov 2005 → Sep 2006 osteoarthritis, knee Laboratoires NEGMA Completed No outcome recorded
Phase not applicable1 trial
NCT07199933 Oct 2025 → Oct 2026 expected metabolic dysfunction-associated steatotic liver disease Hongyan Wu Not yet recruiting No outcome recorded
Also used as a comparator or background therapy in 4 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 23 trials
Phase 2 NCT05226754 Comparator Apr 2022 → Jun 2023 COVID-19 University of Campinas, Brazil Unknown No outcome recorded
Phase 2 NCT03208309 Comparator Jan 2013 → Aug 2015 type 2 diabetes mellitus ANS Pharma Completed No outcome recorded
Phase 2 NCT02177643 Comparator Jan 2013 → Aug 2016 type 2 diabetes mellitus University of Campinas, Brazil Unknown No outcome recorded
Phase 31 trial
Phase 3 NCT07549386 Comparator May 2024 → Mar 2025 osteoarthritis Laboratorios Liomont Completed No outcome recorded

Evidence & citations 11 cited values

Every value below carries the sentence it was read from. 39 sources stand behind the page.

FieldValueCited text
Known as Diacerein “AC-203 (diacerein 1% ointment) is a topical formulation of diacerein, well-known for its ability to inhibit IL-1β and other proinflammatory cytokines.” NCT06073132
28

Diacerein (Artrodar ®) participants take 1x1 with evening meal for 1 month” NCT04318041

NCT03208309

NCT03472534

NCT03754634

NCT00445276

NCT07352306

NCT07549386

NCT02242149

NCT03473184

NCT01906801

NCT06912035

NCT01298882

NCT03389308

NCT02060552

NCT03404479

NCT03154333

NCT03473197

NCT02177643

NCT00451360

NCT04917679

NCT03472287

NCT07199933

NCT00685542

NCT02688400

NCT01120015

NCT05226754

NCT01264211

NCT03472547

Known as AC-201 ClinicalTrials.gov intervention name — accepted as the source's own label NCT06972888
4

NCT02994147

NCT02287818

NCT01276106

NCT01712204

Known as AC-201 CR tablet AC-201 CR tabletNCT02287818
Known as AC-203 AC-203 (diacerein 1% ointment) is a topical formulation of diacerein, well-known for its ability to inhibit IL-1β and other proinflammatory cytokines.” NCT06073132
2

NCT03468322

NCT03286582

Known as Artrodar “Diacerein (Artrodar ®) participants take 1x1 with evening meal for 1 month” NCT04318041
Known as DAR “Diacerein (DAR) is an anthraquinone derivative drug whose active metabolite is rhein.” PMID 32534337 Jun 2020
Known as Diacerhein ClinicalTrials.gov intervention name — accepted as the source's own label NCT00440661
Action Inhibit “diacerein, an interleukin-1beta inhibitor” PMID 11710710 Nov 2001
Modality Small molecule “Diacerein, a purified compound with anthraquinonic structure” NCT01120015
Route Oral oral IL-1beta inhibitor AC-201” NCT01276106
Target IL1B “AC-201 is an IL-1β modulator” NCT01712204