Drugs / Clobazam

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) ONFI 2011-10-21 fda.gov

Trials 14 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/21 trial
Phase 1/2 NCT01291316 Apr 2010 → Nov 2011 neuropathy, painful University Hospital, Geneva Completed No outcome recorded
Phase 22 trials
Phase 2 NCT02565108 Jan → Jul 2016 epilepsy Jazz Pharmaceuticals Completed No outcome recorded
Phase 2 NCT00162981 Oct 2005 → Aug 2006 generalized epilepsy Lundbeck LLC Completed No outcome recorded
Phase 37 trials
Phase 3 NCT02174094 Mar → Aug 2015 Dravet syndrome H. Lundbeck A/S Withdrawn No outcome recorded
Phase 3 NCT02187809 Mar → Oct 2015 Dravet syndrome H. Lundbeck A/S Terminated No outcome recorded
Phase 3 NCT02374567 Jan 2015 → Jun 2017 anxiety disorder, dementia, depressive disorder, schizophrenia +1 Hannover Medical School Terminated No outcome recorded
Phase 3 NCT02134366 Jul 2014 → Jul 2017 epilepsy syndrome The Cooper Health System Terminated No outcome recorded
Phase 3 NCT01011036 Dec 2009 → Apr 2010 Insel Gruppe AG, University Hospital Bern Completed No outcome recorded
Phase 3 NCT00518713 Aug 2007 → Dec 2009 generalized epilepsy Lundbeck LLC Completed No outcome recorded
Phase 3 NCT01160770 Dec 2005 → Feb 2012 Lennox-Gastaut syndrome Lundbeck LLC Completed No outcome recorded
Phase 43 trials
Phase 4 NCT03371836 Oct 2017 → Dec 2019 anxiety, epilepsy Hugo W. Moser Research Institute at Kennedy Krieger, Inc. Completed No outcome recorded
Phase 4 NCT02726919 Feb 2015 → Jun 2018 epilepsy Pavel Klein Unknown No outcome recorded
Phase 4 NCT01932502 Feb 2013 → Jun 2017 epilepsy St. Joseph's Hospital and Medical Center, Phoenix Unknown No outcome recorded
Phase not applicable1 trial
NCT03678129 Dec 2018 → Jun 2025 autism spectrum disorder King's College London Completed No outcome recorded
Also used as a comparator or background therapy in 6 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 21 trial
Phase 2 NCT02564952 Background Mar 2016 → Jun 2017 epilepsy Jazz Pharmaceuticals Completed No outcome recorded
Phase 32 trials
Phase 3 NCT01713946 Background Apr 2013 → Oct 2017 tuberous sclerosis Novartis Pharmaceuticals Completed No outcome recorded
Phase 3 NCT01179828 Comparator Jul 2010 → Apr 2015 Insel Gruppe AG, University Hospital Bern Completed No outcome recorded
Phase 43 trials
Phase 4 NCT05697614 Comparator Mar → May 2023 epilepsy Dr Cipto Mangunkusumo General Hospital Unknown No outcome recorded
Phase 4 NCT02205931 Comparator Jan 2015 → Jun 2018 epilepsy University College, London Unknown No outcome recorded
Phase 4 NCT00552526 Comparator Nov 2007 → Jan 2011 epilepsy Oslo University Hospital Unknown No outcome recorded

Evidence & citations 17 cited values

Every value below carries the sentence it was read from. 23 sources stand behind the page.

FieldValueCited text
Known as Clobazam “Drugs from ACT groups N03A, N05BA, N05CD, H02A or S01EC will be used including prednisolon,levetiracetam, valproate, carbamazepine, oxcarbazepine, topiramate, felbamate,...” NCT00552526
19

“List of allowed antiepileptic drugs were: valporic acid, carbamazepine, clobazam, N-desmethylclobazam, topiramate,TRI477, TRI476, clonazepam, zonisamide, phenobarbital, phenytoin” NCT01713946

ClobazamNCT02205931

NCT02565108

NCT01160770

NCT00518713

NCT02564952

NCT05697614

NCT03678129

NCT01011036

NCT02134366

NCT01291316

NCT02174094

NCT01932502

NCT00162981

NCT02374567

NCT02187809

NCT01179828

NCT03371836

NCT02726919

Known as Colbazam ChEMBL registry synonym — accepted as the source's own label CHEMBL70418
Known as Frisium ChEMBL registry synonym — accepted as the source's own label CHEMBL70418
Known as H 4723 ChEMBL registry synonym — accepted as the source's own label CHEMBL70418
Known as HR 376 ChEMBL registry synonym — accepted as the source's own label CHEMBL70418
Known as LM 2717 ChEMBL registry synonym — accepted as the source's own label CHEMBL70418
Known as Mystan ChEMBL registry synonym — accepted as the source's own label CHEMBL70418
Known as NSC-336279 ChEMBL registry synonym — accepted as the source's own label CHEMBL70418
Known as Onfi “clobazam (Onfi) when it replaces the pre-existing clonazepam therapy” NCT01932502
Known as Perizam ChEMBL registry synonym — accepted as the source's own label CHEMBL70418
Known as Sympazan ChEMBL registry synonym — accepted as the source's own label CHEMBL70418
Known as Tapclob ChEMBL registry synonym — accepted as the source's own label CHEMBL70418
Known as Urbadan ChEMBL registry synonym — accepted as the source's own label CHEMBL70418
Known as Urbanyl ChEMBL registry synonym — accepted as the source's own label CHEMBL70418
Action Activate “Two agonists at the benzodiazepine-binding site of GABAA-receptors (clobazam and clonazepam) were studied using multiple experimental pain tests.” PMID 23554851 Mar 2013
Modality Small molecule “clobazam, a 1,5-benzodiazepine, as adjunctive therapy for Lennox-Gastaut syndrome (LGS).” PMID 21956725 Sep 2011
Route Oral orally” NCT00162981