Drugs / REGN5381
last change Dec 2025 re-read 3 minutes ago

REGN5381

Protein / enzyme biologic targets NPR1 via activation

Developed for
heart failure · hypertensive disorder
Investigated by
Regeneron Pharmaceuticals

Trials 5

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT05291546 Apr 2022 → Apr 2024 — Regeneron Pharmaceuticals Completed No outcome recorded
Phase 1 NCT04506645 Sep 2020 → Dec 2022 — Regeneron Pharmaceuticals Completed No outcome recorded
Phase 23 trials
Phase 2 NCT06833190 Apr → Oct 2025 hypertensive disorder Regeneron Pharmaceuticals Terminated No outcome recorded Stop: Business
Phase 2 NCT06237309 Apr 2024 → Sep 2025 heart failure Regeneron Pharmaceuticals Terminated No outcome recorded Stop: Business
Phase 2 NCT05353166 Jun 2022 → Jun 2025 heart failure Regeneron Pharmaceuticals Completed No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as REGN5381 ClinicalTrials.gov intervention name — accepted as the source's own label NCT04506645 ↗
4

NCT06237309 ↗

NCT05353166 ↗

NCT06833190 ↗

NCT05291546 ↗

Action Activate “REGN5381 (an NPR1 Agonist)” NCT04506645 ↗
Modality Protein / enzyme biologic “an NPR1 Agonist Antibody” NCT05291546 ↗
Route Intravenous “Single dose REGN5381 administered via IV infusion” NCT04506645 ↗
Target NPR1 “REGN5381 (an NPR1 Agonist)” NCT04506645 ↗