drugset

Drugs / SARS-CoV-2 rS

Follow last change Feb 2026 re-read 2 minutes ago

SARS-CoV-2 rS

also known as CovovaxTM · SARS-CoV-2-rS-PN · SARS-CoV-2-rS-protein-nanoparticle

Developed for: COVID-19
Investigated by: Novavax · Coalition for Epidemic Preparedness Innovations

Trials 2 · a red edge is where a trial was stopped

today NCT04961541 · Ph 1/2 NCT04368988 · Ph 1/2

202120222023202420252026

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 1/2	NCT04961541	Sep → Dec 2021	COVID-19	Novavax	Completed	No outcome recorded
Phase 1/2	NCT04368988	May 2020 → Jun 2022	COVID-19	Novavax	Completed	No outcome recorded

Also used as a comparator or background therapy in 1 trial

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 2	NCT05515042 Comparator	Jul 2022 → Jun 2024 overdue	COVID-19	The Aurum Institute NPC	Active not recruiting	No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

Field	Value	Cited text
Known as	SARS-CoV-2 rS	ClinicalTrials.gov intervention name — accepted as the source's own label NCT05515042 ↗ 2 NCT04368988 ↗ NCT04961541 ↗
Known as	CovovaxTM	“SARS-CoV-2 rS (CovovaxTM): is a recombinant protein nanoparticle vaccine constructed from the SARS-CoV-2 full-length spike (S) glycoprotein co-formulated with Matrix-M1 adjuvant.” NCT05515042 ↗
Known as	SARS-CoV-2-rS-PN	“SARS-CoV-2-rS-protein-nanoparticle (SARS-CoV-2-rS-PN). Participants, investigators, and site staff (except for site pharmacists) were masked to participant treatment assignment.” PMID 41690324 ↗ Feb 2026
Known as	SARS-CoV-2-rS-protein-nanoparticle	“SARS-CoV-2-rS-protein-nanoparticle (SARS-CoV-2-rS-PN). Participants, investigators, and site staff (except for site pharmacists) were masked to participant treatment assignment.” PMID 41690324 ↗ Feb 2026
Modality	Vaccine	“SARS-CoV-2 recombinant spike protein vaccine” PMID 35963274 ↗ Aug 2022
Route	Intramuscular	“Alternating intramuscular (deltoid) injections of SARS-CoV-2 rS (0.6 mL) on Days 0 and 21.” NCT04368988 ↗