Drugs / ROPSACITINIB
last change Oct 2023 re-read 2 minutes ago

ROPSACITINIB

also known as PF-06826647 · PF-647

Small molecule targets TYK2 via inhibition

Developed for
psoriasis · hidradenitis suppurativa · ulcerative colitis
Investigated by
Pfizer

Trials 6 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT04591262 Nov 2020 → Jan 2021 Pfizer Completed No outcome recorded
Phase 1 NCT04134715 Oct 2019 → Jan 2020 Pfizer Completed No outcome recorded
Phase 1 NCT03210961 Jul 2017 → Jan 2019 psoriasis Pfizer Completed No outcome recorded
Phase 23 trials
Phase 2 NCT04209556 Sep 2020 → Oct 2023 ulcerative colitis Pfizer Withdrawn No outcome recorded
Phase 2 NCT04092452 Dec 2019 → Jan 2022 hidradenitis suppurativa Pfizer Completed No outcome recorded
Phase 2 NCT03895372 Jun 2019 → May 2020 psoriasis Pfizer Completed No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 8 sources stand behind the page.

FieldValueCited text
Known as ROPSACITINIB ChEMBL registry synonym — accepted as the source's own label CHEMBL4459585
Known as PF-06826647 ClinicalTrials.gov intervention name — accepted as the source's own label NCT04209556
5

NCT03210961

NCT04134715

NCT04591262

NCT03895372

NCT04092452

Known as PF-647 ChEMBL registry synonym — accepted as the source's own label CHEMBL4459585
Action Inhibit “Tyrosine-protein kinase TYK2 inhibitor” CHEMBL4459585
1

“the TYK2 inhibitor PF-06826647” PMID 38279383 Dec 2020

Modality Small molecule CHEMBL4459585
Route Oral “assessed once daily oral dosing of PF-06826647 in participants with plaque psoriasis” PMID 38279383 Dec 2020
Target TYK2 “Tyrosine-protein kinase TYK2 inhibitor” CHEMBL4459585