autologous dendritic cell vaccine

Developed for: melanoma · acute myeloid leukemia · cutaneous melanoma · Ewing sarcoma · neuroblastoma · osteosarcoma · primary cutaneous T-cell lymphoma · rhabdomyosarcoma
+3 more
· Sezary syndrome · soft tissue sarcoma · synovial sarcoma
Investigated by: Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS · Dutch Cancer Society · N.N. Petrov National Medical Research Center of Oncology · Radboud University Medical Center · Solving Kids' Cancer · University Hospital, Antwerp
+2 more
· University of Louisville · University of Pittsburgh

200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 12 trials
Phase 1	NCT01241162	Aug 2010 → Oct 2016	Ewing sarcoma, neuroblastoma, osteosarcoma, rhabdomyosarcoma +1	University of Louisville	Completed	No outcome recorded
Phase 1	NCT00834002	Mar 2005 → Nov 2007	acute myeloid leukemia	University Hospital, Antwerp	Completed	No outcome recorded
Phase 1/22 trials
Phase 1/2	NCT01883518	Jun 2013 → Sep 2020	soft tissue sarcoma	N.N. Petrov National Medical Research Center of Oncology	Unknown	No outcome recorded
Phase 1/2	NCT00243529	Apr 2004 → Feb 2009	melanoma	Radboud University Medical Center	Completed	No outcome recorded
Phase 23 trials
Phase 2	NCT02718391	Aug 2015 → Nov 2019	melanoma	Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS	Terminated	No outcome recorded
Phase 2	NCT01973322	Oct 2013 → Sep 2023	cutaneous melanoma	Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS	Completed	No outcome recorded
Phase 2	NCT00099593	Sep 2004 → Sep 2007	Sezary syndrome, primary cutaneous T-cell lymphoma	University of Pittsburgh	Completed	No outcome recorded

Also used as a comparator or background therapy in 1 trial

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 1/2	NCT01530698 Comparator	Apr 2010 → Nov 2014	melanoma	Radboud University Medical Center	Completed	No outcome recorded

Every value below carries the sentence it was read from. 8 sources stand behind the page.

Field	Value	Cited text
Known as	Autologous Dendritic Cell Vaccine	“intradermal injection of WT1-RNA-electroporated autologous dendritic cell vaccine (therapeutic cell vaccine)” NCT00834002 ↗ 7 “Intradermal Autologous Dendritic Cell Vaccine loaded with autologous tumor lysate or homogenate” NCT01973322 ↗ NCT00099593 ↗ NCT01883518 ↗ NCT00243529 ↗ NCT02718391 ↗ NCT01241162 ↗ NCT01530698 ↗
Action	Deplete	“may induce an effective immune response to kill residual leukemic cells” NCT00834002 ↗
Modality	Vaccine	“DC-tumor cell vaccines have several features” NCT00099593 ↗
Route	Other	“intradermal injection” NCT00834002 ↗