Drugs / AZD2389
last change Jul 2026 re-read 2 minutes ago

AZD2389

Small molecule targets FAP via inhibition

Developed for
cirrhosis of liver · fibrotic liver disease
Investigated by
AstraZeneca · Parexel · CTC Clinical Trial Consultants AB · Karolinska Institutet

Trials 8 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 16 trials
Phase 1 NCT07069725 May 2025 → Jul 2026 overdue cirrhosis of liver, fibrotic liver disease AstraZeneca Active not recruiting No outcome recorded
Phase 1 NCT06974565 May → Jul 2025 liver disorder AstraZeneca Completed No outcome recorded
Phase 1 NCT06973005 May → Jul 2025 liver disorder AstraZeneca Completed No outcome recorded
Phase 1 NCT06846528 Feb → Apr 2025 AstraZeneca Completed No outcome recorded
Phase 1 NCT06812780 Feb → Sep 2025 AstraZeneca Completed No outcome recorded
Phase 1 NCT06138795 Nov 2023 → Aug 2025 AstraZeneca Completed No outcome recorded
Phase 22 trials
Phase 2 NCT07610837 May 2026 → Jul 2027 expected cirrhosis of liver, fibrotic liver disease AstraZeneca Recruiting No outcome recorded
Phase 2 NCT06750276 Dec 2024 → Jul 2025 cirrhosis of liver, fibrotic liver disease AstraZeneca Completed No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 8 sources stand behind the page.

FieldValueCited text
Known as AZD2389 “Drug: AZD2389NCT06973005
7

NCT07610837

NCT06750276

NCT06812780

NCT06138795

NCT06974565

NCT06846528

NCT07069725

Action Inhibit inhibitor of FAP” NCT07610837
Modality Small molecule small moleculeNCT07610837
Route Oral “Participants will receive AZD2389 orally as a single ascending dose or multiple ascending dose.” NCT06138795
Target FAP “inhibitor of FAPNCT07610837