Drugs / AZD2389
last change Jul 2026 re-read 9 days ago

AZD2389

Small molecule targets FAP via inhibition

Developed for
cirrhosis of liver · fibrotic liver disease
Investigated by
AstraZeneca · Parexel · CTC Clinical Trial Consultants AB · Karolinska Institutet

Trials 8

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 16 trials
Phase 1 NCT07069725 May 2025 → Jul 2026 overdue cirrhosis of liver, fibrotic liver disease AstraZeneca Active not recruiting No outcome recorded
Phase 1 NCT06974565 May → Jul 2025 liver disorder AstraZeneca Completed No outcome recorded
Phase 1 NCT06973005 May → Jul 2025 liver disorder AstraZeneca Completed No outcome recorded
Phase 1 NCT06846528 Feb → Apr 2025 — AstraZeneca Completed No outcome recorded
Phase 1 NCT06812780 Feb → Sep 2025 — AstraZeneca Completed No outcome recorded
Phase 1 NCT06138795 Nov 2023 → Aug 2025 — AstraZeneca Completed No outcome recorded
Phase 22 trials
Phase 2 NCT07610837 May 2026 → Jul 2027 expected cirrhosis of liver, fibrotic liver disease AstraZeneca Recruiting No outcome recorded
Phase 2 NCT06750276 Dec 2024 → Jul 2025 cirrhosis of liver, fibrotic liver disease AstraZeneca Completed No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 8 sources stand behind the page.

FieldValueCited text
Known as AZD2389 “Drug: AZD2389” NCT06973005 ↗
7

NCT06138795 ↗

NCT06750276 ↗

NCT06974565 ↗

NCT07610837 ↗

NCT06846528 ↗

NCT07069725 ↗

NCT06812780 ↗

Action Inhibit “inhibitor of FAP” NCT07610837 ↗
Modality Small molecule “small molecule” NCT07610837 ↗
Route Oral “Participants will receive AZD2389 orally as a single ascending dose or multiple ascending dose.” NCT06138795 ↗
Target FAP “inhibitor of FAP” NCT07610837 ↗