Drugs / dexfadrostat phosphate
last change Apr 2023 re-read 3 minutes ago

dexfadrostat phosphate

also known as DP13

targets CYP11B2 via inhibition

Developed for
primary aldosteronism
Investigated by
Damian Pharma AG · Covance · Foundation for Therapeutic Research, Lausanne · Insel Gruppe AG, University Hospital Bern

Trials 2

20172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT03046589 Mar 2017 → Mar 2018 — Damian Pharma AG Completed No outcome recorded
Phase 21 trial · 1 met primary
Phase 2 NCT04007406 Nov 2019 → May 2022 primary aldosteronism Damian Pharma AG Completed Met primary

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 3 sources stand behind the page.

FieldValueCited text
Known as dexfadrostat phosphate “We evaluated the safety and efficacy of dexfadrostat phosphate (DP13), a novel aldosterone synthase (CYP11B2) inhibitor, in healthy participants.” PMID 36914591 ↗ Apr 2023
1

NCT04007406 ↗

Known as DP13 ClinicalTrials.gov intervention name — accepted as the source's own label NCT03046589 ↗
Action Inhibit “a novel aldosterone synthase (CYP11B2) inhibitor” PMID 36914591 ↗ Apr 2023
Route Oral “received oral DP13 4, 8 or 16 mg once daily for 8 days” PMID 36914591 ↗ Apr 2023
Target CYP11B2 “a novel aldosterone synthase (CYP11B2) inhibitor” PMID 36914591 ↗ Apr 2023