Drugs / Sulthiame
Sulthiame
Trials 2 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT03400189 | Feb → May 2018 | epilepsy | Centre Hospitalier Universitaire Vaudois | Completed | No outcome recorded |
| Phase 31 trial | ||||||
| Phase 3 | NCT00471744 | Jun 2006 → Jul 2008 | self-limited epilepsy with centrotemporal spikes | Ludwig-Maximilians - University of Munich | Terminated | No outcome recorded |
Also used as a comparator or background therapy in 1 trial
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 2 | NCT05236842 Comparator | Nov 2021 → Aug 2023 | obstructive sleep apnea syndrome | Desitin Arzneimittel GmbH | Completed | No outcome recorded |
Evidence & citations 11 cited values
Every value below carries the sentence it was read from. 5 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Sulthiame | ClinicalTrials.gov intervention name — accepted as the source's own label NCT05236842 ↗ |
| Known as | Conadil | ChEMBL registry synonym — accepted as the source's own label CHEMBL328560 ↗ |
| Known as | Ospolot | ChEMBL registry synonym — accepted as the source's own label CHEMBL328560 ↗ |
| Known as | RIKER 594 | ChEMBL registry synonym — accepted as the source's own label CHEMBL328560 ↗ |
| Known as | STM | “three different doses of sulthiame (STM) compared to placebo on sleep apnea activity in adult patients with obstructive sleep apnea.” NCT05236842 ↗1“Sulthiame (STM) is widely used as an antiepileptic drug in Europe and Israel.” PMID 34554571 ↗ Sep 2021 |
| Known as | sultiame | “Sulthiame (or sultiame), marketed in the 60's in Germany, Austria, Switzerland, Israel, Australia and Japan under the brand name Ospolot®, has progressively become the...” NCT03400189 ↗ |
| Known as | Sultiamo | ChEMBL registry synonym — accepted as the source's own label CHEMBL328560 ↗ |
| Known as | Trolone | ChEMBL registry synonym — accepted as the source's own label CHEMBL328560 ↗ |
| Action | Inhibit | “Its antiepileptic activity is thought to result from the inhibition of various subtypes of carbonic anhydrase (hCA), in particular cytosolic hCA II, thus inducing a degree of...” NCT03400189 ↗ |
| Modality | Small molecule | — CHEMBL328560 ↗ |
| Route | Oral | “Single oral dose of sulthiame (Ospolot® tablets)” NCT03400189 ↗ |