Drugs / ZILURGISERTIB
ZILURGISERTIB
Trials 4
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT05099445 | Dec 2021 → Feb 2023 | impaired renal function disease | Incyte Corporation | Completed | No outcome recorded |
| Phase 1/22 trials | ||||||
| Phase 1/2 | NCT04582539 | Aug 2021 → Aug 2024 | anemia, myelodysplastic syndrome, plasma cell myeloma | Incyte Corporation | Terminated | No outcome recorded Stop: Business |
| Phase 1/2 | NCT04455841 | Mar 2021 → Apr 2025 | anemia, myelofibrosis | Incyte Corporation | Completed | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT05090891 | May 2022 → Jul 2027 expected | fibrodysplasia ossificans progressiva | Incyte Corporation | Recruiting | No outcome recorded |
News releases announcing trial results or a regulatory action · 1
| Date | Issuer | Release |
|---|---|---|
| 2022-12-10 | Incyte Corporation | Results Incyte Announces Data from Two LIMBER Studies Evaluating Combination Treatments in Patients with Myelofibrosis (MF) Presented at ASH 2022 incyte.com ↗
Initial results of a Phase 1/2 study evaluating the safety and tolerability of INCB00928, an ALK2 inhibitor, show INCB00928 improves anemia in patients with MF both as monotherapy and in combination with ruxolitinib |
All press releases naming this drug 4 releases
Evidence & citations 10 cited values
Every value below carries the sentence it was read from. 6 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | ZILURGISERTIB | ChEMBL registry synonym — accepted as the source's own label CHEMBL5314579 ↗ |
| Known as | INCB-000928 FUMARATE DIHYDRATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL5314579 ↗ |
| Known as | INCB000928 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT05099445 ↗ |
| Known as | NBU-928 | ChEMBL registry synonym — accepted as the source's own label CHEMBL5314579 ↗ |
| Known as | NBU-928 FREE BASE | ChEMBL registry synonym — accepted as the source's own label CHEMBL5314579 ↗ |
| Known as | ZILURGISERTIB FUMARATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL5314579 ↗ |
| Known as | Zilurgisertib fumarate dihydrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL5314579 ↗ |
| Action | Inhibit | “Small-molecule activin receptor-like kinase-2 inhibitor zilurgisertib (INCB000928)” PMID 41360500 ↗ Dec 2025 |
| Modality | Small molecule | “Small-molecule activin receptor-like kinase-2 inhibitor zilurgisertib (INCB000928)” PMID 41360500 ↗ Dec 2025 |
| Route | Oral | “single oral doses of INCB000928” NCT05099445 ↗ |