Drugs / Codrituzumab
last change Jun 2021 re-read 3 minutes ago

Codrituzumab

also known as GC33 · RG-7686 · RO5137382

Monoclonal antibody targets GPC3 via inhibition

Developed for
hepatocellular carcinoma
Investigated by
Chugai Pharmaceutical · Hoffmann-La Roche · Chugai Pharma USA · Memorial Sloan Kettering Cancer Center

Trials 4

20092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT04928677 Jun 2021 → Jun 2027 expected — Memorial Sloan Kettering Cancer Center Recruiting No outcome recorded
Phase 1 NCT00976170 Sep 2009 → Jul 2013 hepatocellular carcinoma Chugai Pharmaceutical Completed No outcome recorded
Phase 1 NCT00746317 Sep 2008 → Oct 2010 hepatocellular carcinoma Chugai Pharmaceutical Completed No outcome recorded
Phase 21 trial · 1 missed
Phase 2 NCT01507168 Feb 2012 → Aug 2015 hepatocellular carcinoma Hoffmann-La Roche Completed Missed primary

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as Codrituzumab ClinicalTrials.gov intervention name — accepted as the source's own label NCT04928677 ↗
Known as GC33 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00746317 ↗
2

NCT00976170 ↗

NCT01507168 ↗

Known as RG-7686 ChEMBL registry synonym — accepted as the source's own label CHEMBL4298089 ↗
Known as RO5137382 “GC33(RO5137382)” NCT00976170 ↗
Action Inhibit “Glypican-3 inhibitor” CHEMBL4298089 ↗
Modality Monoclonal antibody — CHEMBL4298089 ↗
Route Intravenous “IV administration at 4 escalating dose levels.” NCT00746317 ↗
Target GPC3 “Glypican-3 inhibitor” CHEMBL4298089 ↗