Drugs / Tamnorzatinib
last change Dec 2025 re-read 2 minutes ago

Tamnorzatinib

also known as ONO-7475

Small molecule

Developed for
acute leukemia · malignant pancreatic neoplasm · myelodysplastic syndrome · non-small cell lung carcinoma
Investigated by
Ono Pharmaceutical Co., Ltd.

Trials 4 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT06532331 Dec 2023 → Sep 2027 expected malignant pancreatic neoplasm Ono Pharmaceutical Co., Ltd. Active not recruiting No outcome recorded
Phase 1 NCT06525246 Aug 2021 → Jun 2025 non-small cell lung carcinoma Ono Pharmaceutical Co., Ltd. Completed No outcome recorded
Phase 1 NCT03730337 Oct 2018 → Jun 2021 Ono Pharmaceutical Co., Ltd. Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT03176277 Jun 2017 → Dec 2022 acute leukemia, myelodysplastic syndrome Ono Pharmaceutical Co., Ltd. Terminated No outcome recorded

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

FieldValueCited text
Known as Tamnorzatinib Tamnorzatinib (ONO-7475) is a potent and highly selective inhibitor of Axl/Mer.” PMID 41385448 Dec 2025
Known as ONO-7475 ClinicalTrials.gov intervention name — accepted as the source's own label NCT06532331
3

NCT03730337

NCT03176277

NCT06525246

Action Inhibit “Tamnorzatinib (ONO-7475) is a potent and highly selective inhibitor of Axl/Mer.” PMID 41385448 Dec 2025
Modality Small molecule CHEMBL5314429