Drugs / DAPORINAD
DAPORINAD
also known as
APO866 · (E)-DAPORINAD · (E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE · 2016-06-07: APO-866 · APO866(E)-DAPORINAD · DAPORINAD(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE · FK 866 · K 22.175
Small molecule targets NAMPT via inhibition
Trials 3
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT00435084 | Feb 2007 → Feb 2008 | B-cell chronic lymphocytic leukemia | Valerio Therapeutics | Completed | No outcome recorded |
| Phase 22 trials | ||||||
| Phase 2 | NCT00431912 | Feb 2007 → Jan 2011 | primary cutaneous T-cell lymphoma | Valerio Therapeutics | Completed | No outcome recorded |
| Phase 2 | NCT00432107 | Jul 2006 → Feb 2008 | melanoma | Valerio Therapeutics | Completed | No outcome recorded |
Evidence & citations 13 cited values
Every value below carries the sentence it was read from. 4 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | DAPORINAD | ChEMBL registry synonym — accepted as the source's own label CHEMBL566757 ↗ |
| Known as | (E)-DAPORINAD | ChEMBL registry synonym — accepted as the source's own label CHEMBL566757 ↗ |
| Known as | (E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE | ChEMBL registry synonym — accepted as the source's own label CHEMBL566757 ↗ |
| Known as | 2016-06-07: APO-866 | ChEMBL registry synonym — accepted as the source's own label CHEMBL566757 ↗ |
| Known as | APO866 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT00435084 ↗ |
| Known as | APO866(E)-DAPORINAD | ChEMBL registry synonym — accepted as the source's own label CHEMBL566757 ↗ |
| Known as | DAPORINAD(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE | ChEMBL registry synonym — accepted as the source's own label CHEMBL566757 ↗ |
| Known as | FK 866 | ChEMBL registry synonym — accepted as the source's own label CHEMBL566757 ↗ |
| Known as | K 22.175 | ChEMBL registry synonym — accepted as the source's own label CHEMBL566757 ↗ |
| Action | Inhibit | “specifically inhibiting the biosynthesis of NAD+ from niacinamide” NCT00431912 ↗1“Nicotinamide phosphoribosyltransferase inhibitor” CHEMBL566757 ↗ |
| Modality | Small molecule | — CHEMBL566757 ↗ |
| Route | Intravenous | “APO866 is administered by intravenous infusion continuously for 96 hours” NCT00431912 ↗ |
| Target | NAMPT | “Nicotinamide phosphoribosyltransferase inhibitor” CHEMBL566757 ↗ |