Drugs / SCRI-CAR19
last change Aug 2025 re-read 3 minutes ago

SCRI-CAR19

Cell therapy targets CD19 via depletion

Developed for
B-cell acute lymphoblastic leukemia
Investigated by
Seattle Children's Hospital

Trials 1

20142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/2 NCT02028455 Feb 2014 → Aug 2021 overdue B-cell acute lymphoblastic leukemia Seattle Children's Hospital Active not recruiting No outcome recorded

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 3 sources stand behind the page.

FieldValueCited text
Known as SCRI-CAR19 “This study reports outcomes of Pediatric Leukemia Adoptive Therapy 02 (PLAT-02), a phase 2 trial of SCRI-CAR19, a second-generation chimeric antigen receptor (CAR) T-cell...” PMID 40233328 ↗ Aug 2025
Action Deplete “The CAR enables the T cell to recognize and kill the leukemic cell through the recognition of CD19” NCT02028455 ↗
Modality Cell therapy “a second-generation chimeric antigen receptor (CAR) T-cell product” PMID 40233328 ↗ Aug 2025
Target CD19 “a second-generation CD19-specific CAR” PMID 35580141 ↗ Jul 2022