Drugs / XRD-0394
last change Nov 2025 re-read 3 minutes ago

XRD-0394

Small molecule targets ATM via inhibition

Developed for
cancer · high grade astrocytic tumor · metastatic neoplasm
Investigated by
NYU Langone Health · XRad Therapeutics Inc

Trials 2

202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT06829173 Nov 2025 → May 2027 expected high grade astrocytic tumor NYU Langone Health Recruiting No outcome recorded
Phase 11 trial
Phase 1 NCT05002140 Aug 2021 → Jul 2023 cancer, metastatic neoplasm XRad Therapeutics Inc Completed No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as XRD-0394 ClinicalTrials.gov intervention name — accepted as the source's own label NCT05002140 ↗
1

NCT06829173 ↗

Action Inhibit “dual inhibitor of ataxia telangiectasia mutated kinase (ATM) and deoxyribonucleic acid (DNA)-dependent protein kinase (DNA-PK)” NCT05002140 ↗
Modality Small molecule “XRD-0394 is a novel, potent, oral, small molecule dual inhibitor” NCT05002140 ↗
Route Oral “Administered orally” NCT06829173 ↗
Target ATM “dual inhibitor of ataxia telangiectasia mutated kinase (ATM)” NCT06829173 ↗