Drugs / Polihexanide
Polihexanide
also known as
Polyhexamethylene biguanide · PHMB · Akantior · Cosmocil cq · Lavasept · Microcare mbg · Polihexanida · Polihexanide hydrochloride · +5 more
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | EU (EMA) | Akantior | — | 2024-08-22 | europa.eu ↗ |
Trials 7
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 21 trial | ||||||
| Phase 2 | NCT05306431 | Jun 2022 | pulpitis | Altamash Institute of Dental Medicine | Completed | No outcome recorded |
| Phase 32 trials · 1 met primary | ||||||
| Phase 3 | NCT04055233 | Feb 2015 → Sep 2018 | — | Johannes Lauscher | Completed | Met primary |
| Phase 3 | NCT02394821 | Sep 2013 → Jul 2014 | neoplasm | University of Sao Paulo | Completed | No outcome recorded |
| Phase 43 trials | ||||||
| Phase 4 | NCT06633588 | May 2025 → Jun 2026 | staphylococcus aureus infection | Swiss Paraplegic Research, Nottwil | Completed | No outcome recorded |
| Phase 4 | NCT06338163 | Jul 2024 → Jun 2025 | — | Marco Catarci | Unknown | No outcome recorded |
| Phase 4 | NCT01330706 | Feb 2010 → Mar 2011 | nail disorder, skin disorder | Universidad Complutense de Madrid | Completed | No outcome recorded |
| Phase not applicable1 trial | ||||||
| — | NCT02375178 | Aug → Oct 2014 | periodontal disorder, smooth surface dental caries | Universidade do Vale do Sapucai | Completed | No outcome recorded |
| Comparator or background therapy4 trials | ||||||
| Phase 3 | NCT06213649 Background | Jul 2024 → Jul 2029 expected | Acanthamoeba keratitis | Jeremy Keenan, MD, MPH | Recruiting | No outcome recorded |
| Phase 3 | NCT03274895 Comparator | Aug 2017 → Jun 2021 | Acanthamoeba keratitis | SIFI SpA | Completed | No outcome recorded |
| Phase 4 | NCT01153620 Comparator | Aug 2010 → Jan 2011 | — | B. Braun Ltd. Centre of Excellence Infection Control | Completed | No outcome recorded |
| — | NCT02621073 Comparator | Nov 2015 → Dec 2017 | infectious disease | Brett Crist | Terminated | No outcome recorded Stop: Enrollment |
Evidence & citations 16 cited values
Every value below carries the sentence it was read from. 12 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Polihexanide | “Polihexanide (Prontosan®) is a modern antiseptic that combines a broad antimicrobial spectrum with low toxicity, high tissue compatibility, no reported adsorption and good...” NCT02621073 ↗5“PURPOSE: To compare topical PHMB (polihexanide) 0.02% (0.2 mg/ml)+ propamidine 0.1% (1 mg/ml) with PHMB 0.08% (0.8 mg/ml)+ placebo (PHMB 0.08%) for Acanthamoeba keratitis (AK)...” PMID 37802392 ↗ Oct 2023 |
| Known as | Akantior | ChEMBL registry synonym — accepted as the source's own label CHEMBL2106939 ↗ |
| Known as | Cosmocil cq | ChEMBL registry synonym — accepted as the source's own label CHEMBL2106939 ↗ |
| Known as | Lavasept | ClinicalTrials.gov intervention name — accepted as the source's own label NCT01153620 ↗ |
| Known as | Microcare mbg | ChEMBL registry synonym — accepted as the source's own label CHEMBL2106939 ↗ |
| Known as | PHMB | “PURPOSE: To compare topical PHMB (polihexanide) 0.02% (0.2 mg/ml)+ propamidine 0.1% (1 mg/ml) with PHMB 0.08% (0.8 mg/ml)+ placebo (PHMB 0.08%) for Acanthamoeba keratitis (AK)...” PMID 37802392 ↗ Oct 20231“Polyhexamethylene biguanide (PHMB)” NCT06213649 ↗ |
| Known as | Polihexanida | ChEMBL registry synonym — accepted as the source's own label CHEMBL2106939 ↗ |
| Known as | Polihexanide hydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL2106939 ↗ |
| Known as | Polyhexamethylene biguanide | ClinicalTrials.gov intervention name — accepted as the source's own label NCT02375178 ↗ |
| Known as | Polyhexanide | ClinicalTrials.gov intervention name — accepted as the source's own label NCT06633588 ↗ |
| Known as | Prontosan | “Polihexanide (Prontosan®) is a modern antiseptic that combines a broad antimicrobial spectrum with low toxicity, high tissue compatibility, no reported adsorption and good...” NCT02621073 ↗ |
| Known as | Purista | ChEMBL registry synonym — accepted as the source's own label CHEMBL2106939 ↗ |
| Known as | Serasept | “Polihexanide; Serasept” NCT04055233 ↗ |
| Known as | Vantocil | ChEMBL registry synonym — accepted as the source's own label CHEMBL2106939 ↗ |
| Modality | Other / unclassified | “Polihexanide (Prontosan®) is a modern antiseptic” NCT02621073 ↗ |
| Route | Topical | “placed on the wound” NCT01153620 ↗ |