Drugs / bireociclib
last change Dec 2025 re-read 2 minutes ago

bireociclib

also known as XZP-3287

Small molecule targets CDK4 via inhibition

Developed for
breast cancer · metastatic neoplasm
Investigated by
Sihuan Pharmaceutical Holdings Group Ltd.

Trials 1 · a red edge is where a trial was stopped

20192020202120222023202420252026
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/2 NCT04539496 May 2018 → Jul 2023 overdue breast cancer, metastatic neoplasm Sihuan Pharmaceutical Holdings Group Ltd. Active not recruiting No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as bireociclib Bireociclib (XZP-3287) is a novel selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor, with a favorable safety profile demonstrated in preclinical and phase I studies.” PMID 40013319 Feb 2025
Known as XZP-3287 “Bireociclib (XZP-3287) is a novel selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor, with a favorable safety profile demonstrated in preclinical and phase I studies.” PMID 40013319 Feb 2025
Action Inhibit “the novel selective small molecule CDK4/6 inhibitor bireociclib” PMID 41063198 Oct 2025
Modality Small molecule “the novel selective small molecule CDK4/6 inhibitor bireociclib” PMID 41063198 Oct 2025
Target CDK4 “the novel selective small molecule CDK4/6 inhibitor bireociclib” PMID 41063198 Oct 2025