Drugs / Perflubron
Perflubron
also known as
perfluorooctylbromide · PFOB · Imagent · Liquivent · N-perfluorooctyl bromide · Perfluorocaprylyl bromide · Perfluoroctyl bromide
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | IMAGENT | — | 1993-08-13 | fda.gov ↗ |
Trials 2 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 2 | NCT04738136 | Sep → Oct 2021 | COVID-19 | SolAeroMed Inc. | Suspended | No outcome recorded |
| Phase 2 | NCT04949386 | Sep → Dec 2021 | COVID-19, long COVID-19 | SolAeroMed Inc. | Unknown | No outcome recorded |
Also used as a comparator or background therapy in 2 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT03041740 Comparator | Jun 2017 → Jun 2019 | bronchopulmonary dysplasia | Children's Hospital of Philadelphia | Completed | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT02334553 Comparator | Feb → Nov 2015 | asthma | SolAeroMed Inc. | Completed | No outcome recorded |
Evidence & citations 10 cited values
Every value below carries the sentence it was read from. 6 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Perflubron | “It contains a potent bronchodilator gas (carbon dioxide or CO2) and nebulized perflubron (a synthetic surfactant possessing mucolytic properties).” PMID 29914544 ↗ Jun 2018 |
| Known as | Imagent | ChEMBL registry synonym — accepted as the source's own label CHEMBL1200866 ↗ |
| Known as | Liquivent | ChEMBL registry synonym — accepted as the source's own label CHEMBL1200866 ↗ |
| Known as | N-perfluorooctyl bromide | ChEMBL registry synonym — accepted as the source's own label CHEMBL1200866 ↗ |
| Known as | Perfluorocaprylyl bromide | ChEMBL registry synonym — accepted as the source's own label CHEMBL1200866 ↗ |
| Known as | Perfluoroctyl bromide | ChEMBL registry synonym — accepted as the source's own label CHEMBL1200866 ↗ |
| Known as | perfluorooctylbromide | “S-1226 has two components delivered by inhalation. It is a mixture of perfluorooctylbromide (PFOB) delivered in gas/aerosol/vapor form within a medical gas mixture containing 8% CO2.” NCT04949386 ↗2“It is a mixture of perfluorooctylbromide (PFOB) delivered in vapour form within a medical gas mixture containing CO2” NCT04738136 ↗ |
| Known as | PFOB | “S-1226 has two components delivered by inhalation. It is a mixture of perfluorooctylbromide (PFOB) delivered in gas/aerosol/vapor form within a medical gas mixture containing 8% CO2.” NCT04949386 ↗2“The drug S1226(8%), consists of Perflubron (PFOB) and 8% CO2 delivered as an aerosol/vapour/gas mixture with a Circulaire nebulizer.” NCT02334553 ↗ “It is a mixture of perfluorooctylbromide (PFOB) delivered in vapour form within a medical gas mixture containing CO2” NCT04738136 ↗ |
| Modality | Other / unclassified | “nebulized perflubron (a synthetic surfactant possessing mucolytic properties)” PMID 29914544 ↗ Jun 2018 |
| Route | Inhaled | “administered by nebulization” NCT02334553 ↗ |