Drugs / KM-001
last change Nov 2024 re-read 3 minutes ago

KM-001

targets TRPV3 via inhibition

Developed for
pachyonychia congenita · punctate palmoplantar keratoderma type 1 · neurodermatitis
Investigated by
Orvida Pharma · Bioskin GmbH

Trials 3

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT05956314 Mar 2023 → Nov 2024 pachyonychia congenita, punctate palmoplantar keratoderma type 1 Orvida Pharma Completed No outcome recorded
Phase 1 NCT05435638 Jul 2022 → Sep 2024 pachyonychia congenita, punctate palmoplantar keratoderma type 1 Orvida Pharma Completed No outcome recorded
Phase 1 NCT05454462 May 2022 → Apr 2023 neurodermatitis Orvida Pharma Completed No outcome recorded

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 3 sources stand behind the page.

FieldValueCited text
Known as KM-001 ClinicalTrials.gov intervention name — accepted as the source's own label NCT05435638 ↗
2

NCT05956314 ↗

NCT05454462 ↗

Action Inhibit “inhibition of TRPV3 by specific antagonists” NCT05956314 ↗
Route Topical “with 1% topical KM-001” NCT05435638 ↗
Target TRPV3 “a potent and selective TRPV3 antagonist” NCT05956314 ↗