Drugs / Tesaglitazar
last change Jan 2007 re-read 2 minutes ago

Tesaglitazar

also known as AR-H-039242 · AR-H039242XX · AZ-242 · BR-44608 · Galida

Small molecule targets PPARA, PPARG via activation

Developed for
type 2 diabetes mellitus
Investigated by
AstraZeneca

Trials 17 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 24 trials
Phase 2 NCT00263965 Aug 2005 → Jul 2006 type 2 diabetes mellitus AstraZeneca Terminated No outcome recorded
Phase 2 NCT00229684 Sep 2004 → Jun 2006 type 2 diabetes mellitus AstraZeneca Terminated No outcome recorded
Phase 2 NCT00261417 May 2004 → Oct 2005 type 2 diabetes mellitus AstraZeneca Terminated No outcome recorded
Phase 2 NCT00280865 Apr 2002 → Jun 2003 type 2 diabetes mellitus AstraZeneca Completed No outcome recorded
Phase 313 trials
Phase 3 NCT00300105 Oct 2005 → Dec 2006 type 2 diabetes mellitus AstraZeneca Terminated No outcome recorded
Phase 3 NCT00252837 Apr 2005 → Dec 2006 type 2 diabetes mellitus AstraZeneca Terminated No outcome recorded
Phase 3 NCT00261352 Mar 2005 → Dec 2006 type 2 diabetes mellitus AstraZeneca Terminated No outcome recorded
Phase 3 NCT00226330 Mar 2005 → Dec 2006 type 2 diabetes mellitus AstraZeneca Terminated No outcome recorded
Phase 3 NCT00252876 Mar 2005 → Jan 2007 type 2 diabetes mellitus AstraZeneca Terminated No outcome recorded
Phase 3 NCT00229710 Feb 2005 → Dec 2006 type 2 diabetes mellitus AstraZeneca Terminated No outcome recorded
Phase 3 NCT00255541 Sep 2004 → Dec 2006 type 2 diabetes mellitus AstraZeneca Terminated No outcome recorded
Phase 3 NCT00252772 Sep 2004 → Nov 2006 type 2 diabetes mellitus AstraZeneca Terminated No outcome recorded
Phase 3 NCT00214565 Aug 2004 → Oct 2006 type 2 diabetes mellitus AstraZeneca Terminated No outcome recorded
Phase 3 NCT00214591 Aug 2004 → Dec 2006 type 2 diabetes mellitus AstraZeneca Terminated No outcome recorded

Evidence & citations 11 cited values

Every value below carries the sentence it was read from. 19 sources stand behind the page.

FieldValueCited text
Known as Tesaglitazar “A 52-wk Randomised, Double-Blind, Parallel-Group, Multi-Centre, Active-Controlled (Metformin) Study to Evaluate the Efficacy, Safety & Tolerability of Tesaglitazar Therapy When...” NCT00214591
16

“This is a 24-week randomized, double-blind, multi-center, active-controlled (pioglitazone) study of tesaglitazar (0.5 mg and 1 mg) in patients with type 2 diabetes” NCT00214565

NCT00251940

NCT00261352

NCT00280865

NCT00252772

NCT00226330

NCT00300105

NCT00263965

NCT00251953

NCT00261417

NCT00229710

NCT00252876

NCT00229684

NCT00242372

NCT00252837

NCT00255541

Known as AR-H-039242 ChEMBL registry synonym — accepted as the source's own label CHEMBL282686
Known as AR-H039242XX ChEMBL registry synonym — accepted as the source's own label CHEMBL282686
Known as AZ-242 ChEMBL registry synonym — accepted as the source's own label CHEMBL282686
Known as BR-44608 ChEMBL registry synonym — accepted as the source's own label CHEMBL282686
Known as Galida ChEMBL registry synonym — accepted as the source's own label CHEMBL282686
Action Activate “dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist tesaglitazar” PMID 17166340 Dec 2006
2

“Peroxisome proliferator-activated receptor gamma agonist” CHEMBL282686

“Peroxisome proliferator-activated receptor alpha agonist” CHEMBL282686

Modality Small molecule CHEMBL282686
Route Oral oral tesaglitazar” NCT00226330
Target PPARA “Peroxisome proliferator-activated receptor alpha agonist” CHEMBL282686
Target PPARG “Peroxisome proliferator-activated receptor gamma agonist” CHEMBL282686