Drugs / AZD1305
last change Jun 2011 re-read 2 minutes ago

AZD1305

Small molecule targets KCNH2, SCN5A via inhibition

Developed for
atrial fibrillation · atrial flutter · left ventricular failure
Investigated by
AstraZeneca

Trials 13 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 19 trials
Phase 1 NCT00957437 Aug → Nov 2009 AstraZeneca Completed No outcome recorded
Phase 1 NCT00935025 Jul → Nov 2009 AstraZeneca Terminated No outcome recorded
Phase 1 NCT00712465 Aug → Nov 2008 atrial fibrillation AstraZeneca Completed No outcome recorded
Phase 1 NCT00707551 Jul → Nov 2008 AstraZeneca Completed No outcome recorded
Phase 1 NCT00738322 Jul → Oct 2008 AstraZeneca Completed No outcome recorded
Phase 1 NCT00689247 Apr → May 2008 AstraZeneca Completed No outcome recorded
Phase 1 NCT00689403 Feb → Jul 2008 AstraZeneca Completed No outcome recorded
Phase 1 NCT00688831 Jan → May 2008 AstraZeneca Completed No outcome recorded
Phase 1 NCT00689039 Apr 2007 → Jul 2008 AstraZeneca Completed No outcome recorded
Phase 24 trials
Phase 2 NCT00915356 May → Dec 2009 atrial fibrillation AstraZeneca Completed No outcome recorded
Phase 2 NCT00748982 Aug 2008 → Jul 2009 left ventricular failure AstraZeneca Completed No outcome recorded
Phase 2 NCT00643448 Mar → Aug 2008 atrial fibrillation AstraZeneca Completed No outcome recorded
Phase 2 NCT00616629 Jan → Jun 2008 atrial flutter AstraZeneca Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 15 sources stand behind the page.

FieldValueCited text
Known as AZD1305 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00957437
12

NCT00935025

NCT00689247

NCT00712465

NCT00915356

NCT00689039

NCT00688831

NCT00643448

NCT00689403

NCT00738322

NCT00748982

NCT00616629

NCT00707551

Action Inhibit “Sodium channel protein type V alpha subunit blocker” CHEMBL3545169
2

“combined potassium and sodium channel inhibition” PMID 21619383 Jun 2011

“HERG blocker” CHEMBL3545169

Modality Small molecule CHEMBL3545169
Route Intravenous Intravenous infusion” NCT00616629
Target KCNH2 “HERG blocker” CHEMBL3545169
Target SCN5A “Sodium channel protein type V alpha subunit blocker” CHEMBL3545169