Drugs / NMRA-335140
NMRA-335140
English name navacaprant
also known as
BTRX-140 · BTRX-335140 · BTRX-335140 hydrochloride · CYM-53093 · CYM-53093 HYDROCHLORIDE · NAVACAPRANT HYDROCHLORIDE · NMRA-140 · NMRA-335140 HCl · +1 more
Small molecule targets OPRK1 via inhibition
Trials 6
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 22 trials · 1 missed | ||||||
| Phase 2 | NCT06429722 | May 2024 → Apr 2025 | bipolar II disorder | Neumora Therapeutics, Inc. | Completed | No outcome recorded |
| Phase 2 | NCT04221230 | Jan 2020 → Apr 2022 | major depressive disorder | Neumora Therapeutics, Inc. | Completed | Missed primary |
| Phase 34 trials | ||||||
| Phase 3 | NCT06058039 | Dec 2023 → May 2026 | major depressive disorder | Neumora Therapeutics, Inc. | Completed | No outcome recorded |
| Phase 3 | NCT06058013 | Dec 2023 → May 2026 | major depressive disorder | Neumora Therapeutics, Inc. | Completed | No outcome recorded |
| Phase 3 | NCT06029439 | Nov 2023 → Jun 2027 expected | major depressive disorder | Neumora Therapeutics, Inc. | Active not recruiting | No outcome recorded |
| Phase 3 | NCT06029426 | Sep 2023 → Dec 2024 | major depressive disorder | Neumora Therapeutics, Inc. | Completed | No outcome recorded |
Evidence & citations 14 cited values
Every value below carries the sentence it was read from. 7 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | NMRA-335140 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT06429722 ↗ |
| Known as | BTRX-140 | ChEMBL registry synonym — accepted as the source's own label CHEMBL4592045 ↗ |
| Known as | BTRX-335140 | ChEMBL registry synonym — accepted as the source's own label CHEMBL4592045 ↗ |
| Known as | BTRX-335140 hydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL4592045 ↗ |
| Known as | CYM-53093 | ChEMBL registry synonym — accepted as the source's own label CHEMBL4592045 ↗ |
| Known as | CYM-53093 HYDROCHLORIDE | ChEMBL registry synonym — accepted as the source's own label CHEMBL4592045 ↗ |
| Known as | NAVACAPRANT HYDROCHLORIDE | ChEMBL registry synonym — accepted as the source's own label CHEMBL4592045 ↗ |
| Known as | NMRA-140 | ChEMBL registry synonym — accepted as the source's own label CHEMBL4592045 ↗ |
| Known as | NMRA-335140 HCl | ChEMBL registry synonym — accepted as the source's own label CHEMBL4592045 ↗ |
| Known as | NMRA-335140 hydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL4592045 ↗ |
| Action | Inhibit | “Kappa opioid receptor antagonist” CHEMBL4592045 ↗ |
| Modality | Small molecule | — CHEMBL4592045 ↗ |
| Route | Oral | “Participants will receive NMRA-335140 at a dose of 80 mg QD, orally” NCT06029426 ↗ |
| Target | OPRK1 | “Kappa opioid receptor antagonist” CHEMBL4592045 ↗ |