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Drugs / PRINABEREL
last change Jun 2010 re-read 3 minutes ago

PRINABEREL

also known as ERB-041 · PF-00913086

Small molecule targets ESR2 via activation

Developed for
endometriosis · Crohn disease · dysmenorrhea · interstitial cystitis · rheumatoid arthritis
Investigated by
Wyeth is now a wholly owned subsidiary of Pfizer

Trials 7

today NCT00434187 · Ph 1 NCT00275379 · not/applicable NCT00316459 · Ph 1 NCT00318500 · Ph 2 NCT00141830 · Ph 2 NCT00110487 · Ph 2 NCT00245947 · Ph 1
200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT00434187 Aug → Oct 2006 — Wyeth is now a wholly owned subsidiary of Pfizer Completed No outcome recorded
Phase 1 NCT00316459 May 2006 → ? long QT syndrome Wyeth is now a wholly owned subsidiary of Pfizer Completed No outcome recorded
Phase 1 NCT00245947 Apr 2004 → Apr 2005 Crohn disease Wyeth is now a wholly owned subsidiary of Pfizer Completed No outcome recorded
Phase 23 trials · 1 missed
Phase 2 NCT00318500 May → Dec 2006 dysmenorrhea, endometriosis Wyeth is now a wholly owned subsidiary of Pfizer Completed No outcome recorded
Phase 2 NCT00141830 Aug 2005 → Oct 2006 rheumatoid arthritis Wyeth is now a wholly owned subsidiary of Pfizer Completed Missed primary
Phase 2 NCT00110487 Jan 2005 → Dec 2006 endometriosis Wyeth is now a wholly owned subsidiary of Pfizer Completed No outcome recorded
Phase not applicable1 trial
— NCT00275379 Aug 2006 → ? interstitial cystitis Wyeth is now a wholly owned subsidiary of Pfizer Withdrawn No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 9 sources stand behind the page.

FieldValueCited text
Known as PRINABEREL ChEMBL registry synonym — accepted as the source's own label CHEMBL450940 ↗
Known as ERB-041 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00141830 ↗
6

NCT00316459 ↗

NCT00275379 ↗

NCT00245947 ↗

NCT00110487 ↗

NCT00434187 ↗

NCT00318500 ↗
Known as PF-00913086 ChEMBL registry synonym — accepted as the source's own label CHEMBL450940 ↗
Action Activate “selective estrogen receptor β agonist, ERB-041” PMID 20556817 ↗ Jun 2010
1

“Estrogen receptor beta agonist” CHEMBL450940 ↗
Modality Small molecule — CHEMBL450940 ↗
Route Oral “oral ERB-041 administered daily” NCT00141830 ↗
Target ESR2 “Estrogen receptor beta agonist” CHEMBL450940 ↗