Drugs / ONZIGOLIDE
last change Jun 2023 re-read 3 minutes ago

ONZIGOLIDE

also known as BIM 23A760 · Dopastatin · TBR-760

targets DRD2, SSTR2, SSTR5 via activation

Developed for
acromegaly · carcinoid syndrome · non-functioning pituitary adenoma
Investigated by
Ipsen

Trials 2

201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 22 trials
Phase 2 NCT01018953 Feb → Dec 2010 carcinoid syndrome Ipsen Terminated No outcome recorded
Phase 2 NCT00994214 Oct 2009 → Feb 2011 acromegaly Ipsen Terminated No outcome recorded
Comparator or background therapy1 trial
Phase 2 NCT04335357 Comparator May 2020 → Mar 2023 non-functioning pituitary adenoma Tiburio Therapeutics Unknown No outcome recorded

Evidence & citations 10 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

FieldValueCited text
Known as ONZIGOLIDE ChEMBL registry synonym — accepted as the source's own label CHEMBL4650342 ↗
Known as BIM 23A760 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00994214 ↗
1

NCT01018953 ↗

Known as Dopastatin ChEMBL registry synonym — accepted as the source's own label CHEMBL4650342 ↗
Known as TBR-760 ClinicalTrials.gov intervention name — accepted as the source's own label NCT04335357 ↗
Action Activate “chimeric dopamine-somatostatin receptor agonist” NCT04335357 ↗
3

“Somatostatin receptor 2 agonist” CHEMBL4650342 ↗

“Somatostatin receptor 5 agonist” CHEMBL4650342 ↗

“Dopamine D2 receptor agonist” CHEMBL4650342 ↗

Modality Other / unclassified “chimeric dopamine-somatostatin receptor agonist” NCT04335357 ↗
Route Subcutaneous “Subcutaneous injections of BIM23A760 once a week.” NCT00994214 ↗
Target DRD2 “Dopamine D2 receptor agonist” CHEMBL4650342 ↗
Target SSTR2 “Somatostatin receptor 2 agonist” CHEMBL4650342 ↗
Target SSTR5 “Somatostatin receptor 5 agonist” CHEMBL4650342 ↗