Drugs / Evobrutinib

Trials 20 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 112 trials
Phase 1 NCT07214922 Jan → Feb 2023 Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany Completed No outcome recorded
Phase 1 NCT07214935 Nov 2022 → Aug 2023 Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany Completed No outcome recorded
Phase 1 NCT05245396 Feb 2022 → Feb 2023 Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany Completed No outcome recorded
Phase 1 NCT05248945 Jan → Jul 2022 Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany Completed No outcome recorded
Phase 1 NCT05064488 Oct → Dec 2021 Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany Completed No outcome recorded
Phase 1 NCT04697511 Jan → Feb 2021 Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany Completed No outcome recorded
Phase 1 NCT04546789 Sep 2020 → May 2021 Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany Completed No outcome recorded
Phase 1 NCT04314024 May → Jun 2020 Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany Completed No outcome recorded
Phase 1 NCT03934502 Apr → Jun 2019 Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany Completed No outcome recorded
Phase 1 NCT03725072 Oct → Dec 2018 Merck KGaA, Darmstadt, Germany Completed No outcome recorded
Phase 24 trials
Phase 2 NCT03233230 Sep 2017 → Sep 2019 rheumatoid arthritis EMD Serono Research & Development Institute, Inc. Completed No outcome recorded
Phase 2 NCT02975349 Mar 2017 → Jan 2018 relapsing-remitting multiple sclerosis EMD Serono Research & Development Institute, Inc. Terminated No outcome recorded
Phase 2 NCT02975336 Jan 2017 → Nov 2019 systemic lupus erythematosus EMD Serono Research & Development Institute, Inc. Terminated No outcome recorded
Phase 2 NCT02784106 Jul 2016 → Apr 2017 rheumatoid arthritis EMD Serono Research & Development Institute, Inc. Completed No outcome recorded
Phase 34 trials
Phase 3 NCT04338061 Jul 2020 → Oct 2023 multiple sclerosis Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany Terminated No outcome recorded
Phase 3 NCT04338022 Jun 2020 → Oct 2023 relapsing-remitting multiple sclerosis Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany Terminated No outcome recorded
Phase 3 NCT04032171 Sep 2019 → May 2020 relapsing-remitting multiple sclerosis EMD Serono Research & Development Institute, Inc. Terminated No outcome recorded
Phase 3 NCT04032158 Aug 2019 → Apr 2020 relapsing-remitting multiple sclerosis EMD Serono Research & Development Institute, Inc. Terminated No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 22 sources stand behind the page.

FieldValueCited text
Known as Evobrutinib “The purpose of this study is to evaluate the pharmacokinetic (PK), pharmacodynamic (PD), and safety and tolerability of evobrutinib after oral administration of immediate...” NCT05245396
12

“Relative Bioavailability of Evobrutinib Tablet Batches” NCT07214922

NCT04338061

NCT04032158

NCT03725072

NCT05064488

NCT03934502

NCT04032171

NCT03436394

NCT04314024

NCT04338022

NCT02975349

NCT05248945

Known as M2951 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02975336
5

NCT03233230

NCT07214935

NCT04697511

NCT04546789

NCT02784106

Known as MSC2364447C ClinicalTrials.gov intervention name — accepted as the source's own label NCT02537028
Action Inhibit “a Bruton's tyrosine kinase inhibitor (BTKi)” PMID 36418156 Nov 2022
Modality Small molecule CHEMBL4072833
Route Oral “Subjects will be administered with MSC2364447C 25 milligrams orally once daily for 4 weeks.” NCT02537028
Target BTK “a Bruton's tyrosine kinase inhibitor (BTKi)” PMID 36418156 Nov 2022