Drugs / St Johns Wort Extract
St Johns Wort Extract
also known as
Each Ucalm(r) tablet contains 300mg of St Johns Wort extract · Hypericum perforatum · Hypericum perforatum extract · Jarsin · Remotiv 250 · Remotiv 500 · Ze 117
targets CYP3A4 via activation
Trials 5
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 13 trials | ||||||
| Phase 1 | NCT03796377 | Feb → Apr 2019 | — | Insel Gruppe AG, University Hospital Bern | Completed | No outcome recorded |
| Phase 1 | NCT03482817 | Feb → May 2018 | — | Max Zeller Soehne AG | Completed | No outcome recorded |
| Phase 1 | NCT01663922 | Aug → Dec 2012 | hepatitis C virus infection | St Stephens Aids Trust | Completed | No outcome recorded |
| Phase 31 trial | ||||||
| Phase 3 | NCT00861978 | Dec 2002 → Nov 2004 | atypical depressive disorder | Cassella-med GmbH & Co. KG | Completed | No outcome recorded |
| Phase 41 trial | ||||||
| Phase 4 | NCT02862236 | Feb 2017 → Feb 2018 | anxiety | Prof. Eldad Yechiam | Completed | No outcome recorded |
Evidence & citations 12 cited values
Every value below carries the sentence it was read from. 7 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | St. John's wort extract | “St. John's wort extract (Jarsin®) twice daily 450 mg po (dose usually used in clinical routine) for 2 weeks.” NCT03796377 ↗ |
| Known as | Each Ucalm(r) tablet contains 300mg of St Johns Wort extract | ClinicalTrials.gov intervention name — accepted as the source's own label NCT01663922 ↗ |
| Known as | Hypericum perforatum | “St John's wort (SJW; Hypericum perforatum) induces CYP3A4 that is involved in the metabolism of the hepatitis C virus (HCV) protease inhibitor boceprevir.” PMID 24610312 ↗ Mar 2014 |
| Known as | Hypericum perforatum extract | ClinicalTrials.gov intervention name — accepted as the source's own label NCT02862236 ↗ |
| Known as | Jarsin | “St. John's wort extract (Jarsin®) twice daily 450 mg po (dose usually used in clinical routine) for 2 weeks.” NCT03796377 ↗ |
| Known as | Remotiv 250 | “We evaluated whether an acute treatment with Remotiv 500 and Remotiv 250 (500 or 250 mg of H. perforatum quantified to either 1 or 0.5 mg of hypericin) improved memory and...” PMID 30382352 ↗ Oct 2018 |
| Known as | Remotiv 500 | “We evaluated whether an acute treatment with Remotiv 500 and Remotiv 250 (500 or 250 mg of H. perforatum quantified to either 1 or 0.5 mg of hypericin) improved memory and...” PMID 30382352 ↗ Oct 2018 |
| Known as | Ze 117 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT03482817 ↗ |
| Action | Activate | “St John's wort (SJW; Hypericum perforatum) induces CYP3A4 that is involved in the metabolism of the hepatitis C virus (HCV) protease inhibitor boceprevir.” PMID 24610312 ↗ Mar 2014 |
| Modality | Traditional medicine (herbal / TCM) | “a herbal remedy commonly used for the treatment of depression (SJW)” NCT01663922 ↗ |
| Route | Oral | “administered orally twice daily (morning and evening)” NCT00861978 ↗ |
| Target | CYP3A4 | “St John's wort (SJW; Hypericum perforatum) induces CYP3A4 that is involved in the metabolism of the hepatitis C virus (HCV) protease inhibitor boceprevir.” PMID 24610312 ↗ Mar 2014 |