Drugs / PIPE-791
last change Jun 2026 re-read 3 minutes ago

PIPE-791

Small molecule targets LPAR1 via inhibition

Developed for
idiopathic pulmonary fibrosis · chronic pain syndrome · multiple sclerosis
Investigated by
Contineum Therapeutics

Trials 4

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT06810245 Feb 2025 → Jan 2026 chronic pain syndrome Contineum Therapeutics Completed No outcome recorded
Phase 1 NCT06683612 Dec 2024 → Jun 2025 idiopathic pulmonary fibrosis, primary progressive multiple sclerosis, secondary progressive multiple sclerosis Contineum Therapeutics Completed No outcome recorded
Phase 1 NCT05983939 Jun 2023 → Feb 2024 multiple sclerosis Contineum Therapeutics Completed No outcome recorded
Phase 21 trial
Phase 2 NCT07284459 Jan 2026 → May 2028 expected idiopathic pulmonary fibrosis Contineum Therapeutics Recruiting No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as PIPE-791 ClinicalTrials.gov intervention name — accepted as the source's own label NCT06810245 ↗
3

NCT05983939 ↗

NCT06683612 ↗

NCT07284459 ↗

Action Inhibit “lysophosphatidic acid receptor 1 (LPAR1) antagonist” PMID 42370792 ↗ Jun 2026
Modality Small molecule “compound 21 that possessed a unique urea scaffold” PMID 42370792 ↗ Jun 2026
Route Oral “Single and multiple ascending oral doses of PIPE-791 tablets.” NCT05983939 ↗
Target LPAR1 “lysophosphatidic acid receptor 1 (LPAR1) antagonist” PMID 42370792 ↗ Jun 2026