drugset
Drugs / Seclidemstat
last change Dec 2025 re-read 2 minutes ago

Seclidemstat

also known as SP-2577 · Seclidemstat mesilate · SECLIDEMSTAT MESYLATE · SP-2577 mesylate

Small molecule

Developed for
clear cell sarcoma · desmoplastic small round cell tumor · Ewing sarcoma · extraskeletal myxoid chondrosarcoma · histiocytoma, Angiomatoid fibrous · myoepithelial tumor · myxoid liposarcoma · cancer
+7 more · chronic myelomonocytic leukemia · fibromyxoid tumor · hypercalcemic type ovarian small cell carcinoma · low grade fibromyxoid sarcoma · myelodysplastic syndrome · ovarian clear cell tumor · ovarian endometrioid adenocarcinoma
Investigated by
Salarius Pharmaceuticals, LLC · HonorHealth Research Institute · M.D. Anderson Cancer Center · Merck Sharp & Dohme LLC · National Pediatric Cancer Foundation

Trials 5 · a red edge is where a trial was stopped

today NCT05266196 · Ph 1/2 NCT04611139 · Ph 1 NCT04734990 · Ph 1/2 NCT03895684 · Ph 1 NCT03600649 · Ph 1
201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT04611139 Dec 2021 → Dec 2023 hypercalcemic type ovarian small cell carcinoma, ovarian clear cell tumor, ovarian endometrioid adenocarcinoma HonorHealth Research Institute Withdrawn No outcome recorded
Phase 1 NCT03895684 Jun 2019 → Apr 2021 cancer Salarius Pharmaceuticals, LLC Completed No outcome recorded
Phase 1 NCT03600649 Jun 2018 → Sep 2025 Ewing sarcoma, clear cell sarcoma, desmoplastic small round cell tumor, extraskeletal myxoid chondrosarcoma +4 Salarius Pharmaceuticals, LLC Unknown No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT05266196 Jan 2022 → Dec 2025 Ewing sarcoma, clear cell sarcoma, desmoplastic small round cell tumor, extraskeletal myxoid chondrosarcoma +4 Salarius Pharmaceuticals, LLC Unknown No outcome recorded
Phase 1/2 NCT04734990 Jul 2021 → Sep 2027 expected chronic myelomonocytic leukemia, myelodysplastic syndrome M.D. Anderson Cancer Center Active not recruiting No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

FieldValueCited text
Known as Seclidemstat “Pilot Feasibility and Efficacy Trial of a Novel Reversible LSD1 Inhibitor SP-2577 (Seclidemstat) Plus Pembrolizumab in Select SWI/SNF-mutant Gynecologic Cancers” NCT04611139 ↗
4

“SP-2577 Seclidemstat” NCT03895684 ↗

NCT05266196 ↗

NCT04734990 ↗

NCT03600649 ↗
Known as Seclidemstat mesilate ChEMBL registry synonym — accepted as the source's own label CHEMBL4297641 ↗
Known as SECLIDEMSTAT MESYLATE ChEMBL registry synonym — accepted as the source's own label CHEMBL4297641 ↗
Known as SP-2577 “A Rollover Protocol to Allow for Continued Access to the LSD1 Inhibitor Seclidemstat (SP-2577)” NCT05266196 ↗
2

NCT03895684 ↗

NCT04611139 ↗
Known as SP-2577 mesylate ChEMBL registry synonym — accepted as the source's own label CHEMBL4297641 ↗
Action Inhibit “LSD1 Inhibitor” NCT03600649 ↗
Modality Small molecule — CHEMBL4297641 ↗
Route Oral “Twice-daily administration of oral seclidemstat” NCT03600649 ↗