Drugs / ADRIFORANT
last change Aug 2020 re-read 2 minutes ago

ADRIFORANT

Small molecule targets HRH4 via inhibition

Developed for
atopic eczema · asthma · psoriasis
Investigated by
Novartis Pharmaceuticals · Pfizer · Ziarco Pharma Ltd

Trials 6 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT00992342 Nov 2009 → Mar 2010 Pfizer Completed No outcome recorded
Phase 1 NCT00856687 Apr → Dec 2009 asthma Pfizer Completed No outcome recorded
Phase 24 trials
Phase 2 NCT03948334 Apr 2019 → Jul 2020 atopic eczema Novartis Pharmaceuticals Terminated No outcome recorded
Phase 2 NCT03517566 Nov 2018 → Jul 2020 atopic eczema Novartis Pharmaceuticals Terminated No outcome recorded
Phase 2 NCT02618616 Jan → Dec 2016 psoriasis Ziarco Pharma Ltd Completed No outcome recorded
Phase 2 NCT02424253 May 2015 → Jan 2016 atopic eczema Ziarco Pharma Ltd Completed No outcome recorded

Evidence & citations 11 cited values

Every value below carries the sentence it was read from. 7 sources stand behind the page.

FieldValueCited text
Known as ADRIFORANT ChEMBL registry synonym — accepted as the source's own label CHEMBL1915540
Known as NVP-ZPL389-NX ChEMBL registry synonym — accepted as the source's own label CHEMBL1915540
Known as PF-03893787 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00992342
1

NCT00856687

Known as PF-3893787 ChEMBL registry synonym — accepted as the source's own label CHEMBL1915540
Known as ZPL-389-NX ChEMBL registry synonym — accepted as the source's own label CHEMBL1915540
Known as ZPL-3893787 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02618616
1

NCT02424253

Known as ZPL389 ClinicalTrials.gov intervention name — accepted as the source's own label NCT03517566
1

NCT03948334

Action Inhibit “Histamine H4 receptor antagonist” CHEMBL1915540
Modality Small molecule CHEMBL1915540
Route Oral Oral, two doses 12 hours apart” NCT00856687
Target HRH4 “Histamine H4 receptor antagonist” CHEMBL1915540