Drugs / Epratuzumab

Trials 27 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT02306629 Nov 2014 → Apr 2015 systemic lupus erythematosus UCB Biopharma S.P.R.L. Completed No outcome recorded
Phase 1 NCT00054834 Mar 2003 → ? non-Hodgkin lymphoma Gilead Sciences Terminated No outcome recorded
Phase 1 NCT00011908 Feb 2001 → Jan 2003 systemic lupus erythematosus National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Completed No outcome recorded
Phase 1/24 trials
Phase 1/2 NCT01449071 Oct 2011 → Mar 2013 systemic lupus erythematosus UCB Pharma Completed No outcome recorded
Phase 1/2 NCT01279707 Jan 2010 → Aug 2014 B-cell acute lymphoblastic leukemia Queen Mary University of London Unknown No outcome recorded
Phase 1/2 NCT00098839 Feb 2005 → Apr 2011 childhood acute lymphoblastic leukemia Children's Oncology Group Completed No outcome recorded
Phase 1/2 NCT00061425 Aug 2000 → Nov 2007 B-cell non-Hodgkin lymphoma Gilead Sciences Completed No outcome recorded
Phase 213 trials
Phase 2 NCT01534403 Jan 2012 → Feb 2015 systemic lupus erythematosus UCB Pharma Completed No outcome recorded
Phase 2 NCT01219816 Nov 2010 → Nov 2016 B-cell acute lymphoblastic leukemia Nantes University Hospital Completed No outcome recorded
Phase 2 NCT00945815 Sep 2010 → Mar 2013 leukemia SWOG Cancer Research Network Completed No outcome recorded
Phase 2 NCT00941928 Jul 2009 → May 2012 childhood malignant neoplasm, leukemia M.D. Anderson Cancer Center Terminated No outcome recorded
Phase 2 NCT00660881 May 2008 → Dec 2011 systemic lupus erythematosus UCB Pharma Completed No outcome recorded
Phase 2 NCT00553501 Mar 2008 → Jul 2010 lymphoma Alliance for Clinical Trials in Oncology Completed No outcome recorded
Phase 2 NCT00624351 Jan 2008 → Aug 2009 systemic lupus erythematosus UCB Pharma Completed No outcome recorded
Phase 2 NCT00383513 Jun 2006 → Jan 2012 systemic lupus erythematosus UCB Pharma Completed No outcome recorded
Phase 2 NCT00301821 Jan 2006 → Oct 2008 lymphoma Alliance for Clinical Trials in Oncology Completed No outcome recorded
Phase 2 NCT00113971 Apr 2005 → Mar 2007 systemic lupus erythematosus UCB Pharma Terminated No outcome recorded
Phase 36 trials
Phase 3 NCT01408576 Jul 2011 → Feb 2016 systemic lupus erythematosus UCB Pharma Completed No outcome recorded
Phase 3 NCT01261793 Dec 2010 → May 2015 systemic lupus erythematosus UCB Pharma Completed No outcome recorded
Phase 3 NCT01262365 Dec 2010 → May 2015 systemic lupus erythematosus UCB Pharma Completed No outcome recorded
Phase 3 NCT00382837 Jan 2007 → ? systemic lupus erythematosus UCB Pharma Withdrawn No outcome recorded
Phase 3 NCT00111306 Jun 2005 → Mar 2007 systemic lupus erythematosus UCB Pharma Terminated No outcome recorded
Phase 3 NCT00022685 Sep 2001 → ? lymphoma Jonsson Comprehensive Cancer Center Unknown No outcome recorded
Phase not applicable1 trial
NCT00398372 Nov 2000 → Jun 2007 Waldenstrom macroglobulinemia, diffuse large B-cell lymphoma, mantle cell lymphoma, marginal zone lymphoma +2 Stanford University Completed No outcome recorded
Also used as a comparator or background therapy in 4 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/22 trials
Phase 1/2 NCT01354457 Background Nov 2010 → Jun 2016 acute lymphoblastic leukemia Nantes University Hospital Unknown No outcome recorded
Phase 1/2 NCT02577094 Background ? → Jan 2017 B-cell acute lymphoblastic leukemia Nantes University Hospital Withdrawn No outcome recorded
Phase 32 trials
Phase 3 NCT01802814 Comparator May 2014 → Jul 2023 acute lymphoblastic leukemia Charite University, Berlin, Germany Completed No outcome recorded
Phase 3 NCT00383214 Comparator May 2005 → Mar 2007 systemic lupus erythematosus UCB Pharma Terminated No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 32 sources stand behind the page.

FieldValueCited text
Known as epratuzumab “hLL2 (epratuzumab)” NCT00054834
30

NCT01219816

NCT00301821

NCT01279707

NCT01534403

NCT02577094

NCT00022685

NCT00042913

NCT00941928

NCT01449071

NCT02306629

NCT00624351

NCT00382837

NCT01262365

NCT00113802

NCT00098839

NCT00660881

NCT01408576

NCT00398372

NCT00061425

NCT00044902

NCT01261793

NCT00111306

NCT00113971

NCT00011908

NCT00553501

NCT00945815

NCT00383214

NCT01354457

NCT00383513

NCT01802814

Known as hLL2 “This study will examine the safety of a new genetically engineered antibody called hLL2 (epratuzumab) in patients with systemic lupus erythematosus (SLE).” NCT00011908
2

“Epratuzumab (hLL2- anti-CD22 humanized antibody)” NCT00113802

NCT00054834

Known as Humanized LL2 IgG “A Phase I Clinical Trial of Immunotherapy With Humanized LL2 IgG (Epratuzumab) in Patients With Systemic Lupus Erythematosus” NCT00011908
Action Deplete “indirect evidence suggests that the antibody is depleting target B lymphocytes” NCT00011908
Modality Monoclonal antibody “hLL2 (epratuzumab), a humanized anti-CD22 monoclonal antibodyNCT00011908
Route Intravenous “The drug is given through a catheter (small plastic tube) placed through a needle in an arm vein” NCT00011908
Target CD22 “Epratuzumab (E) is an unlabeled anti-CD22 monoclonal antibody with efficacy in relapsed DLBCL.” PMID 21673350 Jun 2011