Drugs / Icalcaprant
last change Feb 2026 re-read 9 days ago

Icalcaprant

also known as CVL-354
Developed for
bipolar I disorder · bipolar II disorder · major depressive disorder
Investigated by
AbbVie · Cerevel Therapeutics, LLC · National Institute on Drug Abuse (NIDA)

Trials 6

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT06722417 Nov 2024 → Jan 2025 — AbbVie Completed No outcome recorded
Phase 1 NCT06722430 Nov 2024 → Jan 2025 — AbbVie Completed No outcome recorded
Phase 1 NCT05547542 Mar 2023 → Jul 2024 substance-related disorder Cerevel Therapeutics, LLC Completed No outcome recorded
Phase 1 NCT05138653 Oct 2021 → Jan 2023 — Cerevel Therapeutics, LLC Completed No outcome recorded
Phase 22 trials
Phase 2 NCT06696755 Feb 2026 → Nov 2027 expected bipolar I disorder, bipolar II disorder AbbVie Recruiting No outcome recorded
Phase 2 NCT07276997 Dec 2025 → Sep 2027 expected major depressive disorder AbbVie Recruiting No outcome recorded

Evidence & citations 3 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

FieldValueCited text
Known as Icalcaprant ClinicalTrials.gov intervention name — accepted as the source's own label NCT06722430 ↗
3

NCT06722417 ↗

NCT06696755 ↗

NCT07276997 ↗

Known as CVL-354 ClinicalTrials.gov intervention name — accepted as the source's own label NCT05547542 ↗
1

NCT05138653 ↗

Route Oral “oral dose of CVL-354 10 mg” NCT05138653 ↗