Drugs / Phenformin
Phenformin
also known as
Debei · Dibotin s.r. · Fenformina · NSC-23100 · PHENFORMIN ACETIC ACID SALT · Phenformin hcl · PHENFORMIN HYDROCHLORIDE · Phenformine
Small molecule targets ACE2 via inhibition
Trials 2
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT03026517 | Jan 2017 → Jan 2025 | melanoma | Memorial Sloan Kettering Cancer Center | Completed | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT05003492 | Sep → Oct 2021 | COVID-19 | Amr kamel khalil Ahmed | Unknown | No outcome recorded |
Evidence & citations 13 cited values
Every value below carries the sentence it was read from. 3 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Phenformin | “Patients will be administered study medication (Inhaled 100-150 mg phenformin per day; or, if broken into 3 doses/day, 30-50 mg/dose.” NCT05003492 ↗ |
| Known as | Debei | ChEMBL registry synonym — accepted as the source's own label CHEMBL170988 ↗ |
| Known as | Dibotin s.r. | ChEMBL registry synonym — accepted as the source's own label CHEMBL170988 ↗ |
| Known as | Fenformina | ChEMBL registry synonym — accepted as the source's own label CHEMBL170988 ↗ |
| Known as | NSC-23100 | ChEMBL registry synonym — accepted as the source's own label CHEMBL170988 ↗ |
| Known as | PHENFORMIN ACETIC ACID SALT | ChEMBL registry synonym — accepted as the source's own label CHEMBL170988 ↗ |
| Known as | Phenformin hcl | ChEMBL registry synonym — accepted as the source's own label CHEMBL170988 ↗ |
| Known as | PHENFORMIN HYDROCHLORIDE | ChEMBL registry synonym — accepted as the source's own label CHEMBL170988 ↗ |
| Known as | Phenformine | ChEMBL registry synonym — accepted as the source's own label CHEMBL170988 ↗ |
| Action | Inhibit | “Phenformin is expected to potentially attach to ACE2 receptors and lead to its downregulation, an inhibitory mechanism which may combat and block COVID-19 infection in lung...” NCT05003492 ↗ |
| Modality | Small molecule | — CHEMBL170988 ↗ |
| Route | Inhaled | “The phenformin will be utilized as aerosolized by inhalation for COVID-19 treatment” NCT05003492 ↗ |
| Target | ACE2 | “Phenformin is expected to potentially attach to ACE2 receptors and lead to its downregulation” NCT05003492 ↗ |