Drugs / SIPAGLADENANT
last change Oct 2023 re-read 2 minutes ago

SIPAGLADENANT

also known as KW-6356

Small molecule targets ADORA2A

Developed for
Parkinson disease
Investigated by
Kyowa Kirin, Inc.

Trials 8 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 16 trials
Phase 1 NCT04342273 Mar → Sep 2020 Parkinson disease Kyowa Kirin, Inc. Completed No outcome recorded
Phase 1 NCT04190654 Nov 2019 → Mar 2020 Kyowa Kirin, Inc. Completed No outcome recorded
Phase 1 NCT04070495 Aug → Nov 2019 Parkinson disease Kyowa Kirin, Inc. Completed No outcome recorded
Phase 1 NCT04147910 Aug → Oct 2019 Kyowa Kirin, Inc. Completed No outcome recorded
Phase 1 NCT03970798 May → Jul 2019 Parkinson disease Kyowa Kirin, Inc. Completed No outcome recorded
Phase 1 NCT03830528 Feb → Oct 2019 Parkinson disease Kyowa Kirin, Inc. Completed No outcome recorded
Phase 22 trials
Phase 2 NCT03703570 Sep 2018 → Apr 2020 Parkinson disease Kyowa Kirin, Inc. Completed No outcome recorded
Phase 2 NCT02939391 Sep 2016 → Nov 2017 Parkinson disease Kyowa Kirin, Inc. Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 10 sources stand behind the page.

FieldValueCited text
Known as SIPAGLADENANT ChEMBL registry synonym — accepted as the source's own label CHEMBL5314441
Known as KW-6356 ClinicalTrials.gov intervention name — accepted as the source's own label NCT03830528
7

NCT04342273

NCT04070495

NCT04190654

NCT04147910

NCT03703570

NCT02939391

NCT03970798

Action Inhibit “KW-6356 is a novel selective adenosine A2A receptor antagonist/inverse agonist.” PMID 37948832 Oct 2023
Modality Small molecule CHEMBL5314441
Route Oral “6 mg/day) orally administered as monotherapy for 12 weeks” PMID 37948832 Oct 2023
Target ADORA2A “Adenosine A2a receptor inverse agonist” CHEMBL5314441