CD8-positive WT1 gene-specific CTL clones

Cell therapy targets WT1 via depletion

Developed for: acquired polycythemia vera · acute myeloid leukemia with 11q23 abnormalities · acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) · acute myeloid leukemia with t(8;21)(q22;q22) translocation · B-cell adult acute lymphocytic leukemia · B-cell childhood acute lymphoblastic leukemia · childhood acute myeloid leukemia · childhood myelodysplastic syndrome
+7 more
· chronic myeloid leukemia · chronic myelomonocytic leukemia · essential thrombocythemia · myelodysplastic syndrome with excess blasts · refractory anemia with excess blasts in transformation · T-cell adult acute lymphocytic leukemia · T-cell childhood acute lymphocytic leukemia
Investigated by: Fred Hutchinson Cancer Center · National Cancer Institute (NCI)

today NCT00052520 · Ph 1/2

20022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 1/2	NCT00052520	Sep 2002 → Apr 2011	B-cell adult acute lymphocytic leukemia, B-cell childhood acute lymphoblastic leukemia, T-cell adult acute lymphocytic leukemia, T-cell childhood acute lymphocytic leukemia +11	Fred Hutchinson Cancer Center	Completed	No outcome recorded

Every value below carries the sentence it was read from. 1 source stands behind the page.

Field	Value	Cited text
Known as	CD8-positive WT1 gene-specific CTL clones	“Donors undergo leukapheresis for stem cell harvest to generate CD8-positive WT1 gene-specific CTL clones at the time of allogeneic stem cell transplantation.” NCT00052520 ↗
Action	Deplete	“Immunotherapy given to patients who have undergone donor stem cell transplantation may be a way to eradicate remaining cancer cells” NCT00052520 ↗
Modality	Cell therapy	“adoptive immunotherapy with CD8+ WT1-Specific CTL Clones” NCT00052520 ↗
Route	Intravenous	“CD8-positive WT1 gene-specific CTL clones intravenously (IV)” NCT00052520 ↗
Target	WT1	“CD8-positive WT1 gene-specific CTL clones” NCT00052520 ↗