drugset
Drugs / Arfolitixorin
last change Apr 2025 re-read 2 minutes ago

Arfolitixorin

also known as [6R]-5,10-methylene-tetrahydrofolate · Modufolin · 6R-MTHF · [6R]-5,10-methylenetetrahydrofolate ([6R]-5,10- MTHF) · Arfolitixorina · Arfolitixorine · ISO-901

Small molecule

Developed for
colorectal cancer · colonic neoplasm · colorectal neoplasm · osteosarcoma · rectal cancer
Investigated by
Isofol Medical AB · Charite University, Berlin, Germany · Vastra Gotaland Region

Trials 7 · a red edge is where a trial was stopped

today NCT06922383 · Ph 1/2 NCT04126655 · Ph 1/2 NCT03750786 · Ph 3 NCT02244632 · Ph 1/2 NCT01987102 · Ph 1/2 NCT01681472 · Ph 1/2 NCT01397305 · Ph 1/2
2011201220132014201520162017201820192020202120222023202420252026202720282029
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/26 trials
Phase 1/2 NCT06922383 Apr 2025 → Nov 2028 expected colorectal cancer Isofol Medical AB Recruiting No outcome recorded
Phase 1/2 NCT04126655 Feb 2020 → Oct 2021 colorectal cancer Vastra Gotaland Region Unknown No outcome recorded
Phase 1/2 NCT02244632 Sep 2014 → Jan 2020 colorectal neoplasm Isofol Medical AB Completed No outcome recorded
Phase 1/2 NCT01987102 Dec 2013 → Jan 2017 osteosarcoma Isofol Medical AB Completed No outcome recorded
Phase 1/2 NCT01681472 Sep 2012 → Aug 2013 colonic neoplasm Isofol Medical AB Completed No outcome recorded
Phase 1/2 NCT01397305 Apr 2011 → Oct 2014 rectal cancer Isofol Medical AB Completed No outcome recorded
Phase 31 trial
Phase 3 NCT03750786 Dec 2018 → Nov 2022 colorectal cancer Isofol Medical AB Completed No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT03203564 Comparator Jul → Aug 2017 — Isofol Medical AB Completed No outcome recorded

Evidence & citations 10 cited values

Every value below carries the sentence it was read from. 10 sources stand behind the page.

FieldValueCited text
Known as Arfolitixorin ClinicalTrials.gov intervention name — accepted as the source's own label NCT06922383 ↗
2

NCT04126655 ↗

NCT03750786 ↗
Known as 6R-MTHF ClinicalTrials.gov intervention name — accepted as the source's own label NCT01681472 ↗
Known as [6R]-5,10-methylene-tetrahydrofolate “Arfolitixorin ([6R]-5,10-methylene-tetrahydrofolate) is an immediately active folate and may improve outcomes over the existing standard of care (leucovorin).” PMID 38059497 ↗ Jan 2024
2

NCT01397305 ↗

NCT01987102 ↗
Known as [6R]-5,10-methylenetetrahydrofolate ([6R]-5,10- MTHF) ChEMBL registry synonym — accepted as the source's own label CHEMBL1234270 ↗
Known as Arfolitixorina ChEMBL registry synonym — accepted as the source's own label CHEMBL1234270 ↗
Known as Arfolitixorine ChEMBL registry synonym — accepted as the source's own label CHEMBL1234270 ↗
Known as ISO-901 ChEMBL registry synonym — accepted as the source's own label CHEMBL1234270 ↗
Known as Modufolin ClinicalTrials.gov intervention name — accepted as the source's own label NCT02244632 ↗
1

NCT03203564 ↗
Modality Small molecule — CHEMBL1234270 ↗
Route Intravenous “10, 50, 100, 200, and 500 mg/m2 IV on day 1, day 8 day and day 15 of each 21-day cycle.” NCT01397305 ↗