Drugs / Olinvacimab
last change Dec 2024 re-read 3 minutes ago

Olinvacimab

also known as TTAC-0001 · Tanibirumab

Monoclonal antibody targets KDR

Developed for
glioblastoma · triple-negative breast carcinoma · colorectal cancer · metastatic malignant neoplasm
Investigated by
PharmAbcine · Korean Cancer Study Group · Merck Sharp & Dohme LLC

Trials 7

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT03722342 Jan → Nov 2019 glioblastoma PharmAbcine Unknown No outcome recorded
Phase 1 NCT03720431 Jan 2019 → Mar 2020 triple-negative breast carcinoma PharmAbcine Unknown No outcome recorded
Phase 1 NCT01660360 Nov 2011 → Sep 2013 metastatic malignant neoplasm PharmAbcine Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT04751955 Jan 2022 → Oct 2023 colorectal cancer Korean Cancer Study Group Withdrawn No outcome recorded
Phase 23 trials
Phase 2 NCT04986852 Sep 2021 → Dec 2024 triple-negative breast carcinoma PharmAbcine Terminated No outcome recorded Stop: Enrollment
Phase 2 NCT03856099 Nov 2019 → Jul 2022 glioblastoma PharmAbcine Terminated No outcome recorded Stop: Enrollment
Phase 2 NCT03033524 Feb 2016 → Jun 2017 glioblastoma PharmAbcine Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 7 sources stand behind the page.

FieldValueCited text
Known as Olinvacimab ClinicalTrials.gov intervention name — accepted as the source's own label NCT04751955 ↗
1

NCT04986852 ↗

Known as Tanibirumab ClinicalTrials.gov intervention name — accepted as the source's own label NCT01660360 ↗
Known as TTAC-0001 “* Olinvacimab (TTAC-0001) 16 mg/kg on D1, D8 and D15” NCT04986852 ↗
4

NCT03033524 ↗

NCT03856099 ↗

NCT03722342 ↗

NCT03720431 ↗

Modality Monoclonal antibody “a fully human monoclonal antibody to vascular endothelial growth factor receptor 2 (VEGFR2/KDR)” NCT01660360 ↗
Route Intravenous “Tanibirumab will be administered intravenously to such patients over 60 minutes” NCT01660360 ↗
Target KDR “a fully human monoclonal antibody to vascular endothelial growth factor receptor 2 (VEGFR2/KDR)” NCT01660360 ↗