Drugs / VXM01
last change Dec 2022 re-read 9 days ago

VXM01

Vaccine

Developed for
glioblastoma · colorectal cancer · pancreas disorder
Investigated by
Vaximm GmbH · Merck KGaA, Darmstadt, Germany · Pfizer

Trials 4

2012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT02718443 May 2016 → Aug 2017 glioblastoma Vaximm GmbH Completed No outcome recorded
Phase 1 NCT02718430 Feb 2016 → Mar 2018 colorectal cancer Vaximm GmbH Completed No outcome recorded
Phase 1 NCT01486329 Dec 2011 → Oct 2014 pancreas disorder Vaximm GmbH Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT03750071 Nov 2018 → Dec 2021 glioblastoma Vaximm GmbH Unknown No outcome recorded

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as VXM01 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01486329 ↗
3

NCT02718430 ↗

NCT02718443 ↗

NCT03750071 ↗

Action Inhibit “The immune reaction elicited by VXM01 is expected to disrupt the tumor neovasculature and, consequently, inhibit tumor growth.” PMID 22906006 ↗ Aug 2012
Modality Vaccine “The investigational oral DNA vaccine VXM01 targets the vascular endothelial growth factor receptor 2 (VEGFR-2) and uses Salmonella typhi Ty21a as a vector.” PMID 22906006 ↗ Aug 2012
Route Oral “The investigational oral DNA vaccine VXM01 targets the vascular endothelial growth factor receptor 2 (VEGFR-2)” PMID 22906006 ↗ Aug 2012