Drugs / EMESTEDASTAT
EMESTEDASTAT
Trials 6
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 12 trials | ||||||
| Phase 1 | NCT03830762 | Jan → Dec 2019 | central nervous system disorder, cognitive disorder, neuropathy, small fiber | Actinogen Medical | Completed | No outcome recorded |
| Phase 1 | NCT02616445 | Feb → Aug 2015 | — | Actinogen Medical | Completed | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT04983368 | Jun 2021 → Feb 2022 | Alzheimer disease, cognitive impairment with or without cerebellar ataxia | Actinogen Medical | Completed | No outcome recorded |
| Phase 22 trials | ||||||
| Phase 2 | NCT05657691 | Nov 2022 → Jul 2024 | cognitive disorder, major depressive disorder | Actinogen Medical | Completed | No outcome recorded |
| Phase 2 | NCT02727699 | Mar 2017 → Mar 2019 | Alzheimer disease | Actinogen Medical | Completed | No outcome recorded |
| Phase 2/31 trial | ||||||
| Phase 2/3 | NCT06125951 | Apr 2024 → Oct 2026 expected | Alzheimer disease | Actinogen Medical | Active not recruiting | No outcome recorded |
| Comparator or background therapy1 trial | ||||||
| Phase 1 | NCT01770886 Comparator | Jan → Jul 2013 | — | University of Edinburgh | Completed | No outcome recorded |
Evidence & citations 6 cited values
Every value below carries the sentence it was read from. 9 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | EMESTEDASTAT | ChEMBL registry synonym — accepted as the source's own label CHEMBL6068050 ↗ |
| Known as | UE2343 | “Oral Xanamem® ("UE2343") capsules 5 mg, administered orally once daily.” NCT04983368 ↗ |
| Known as | Xanamem | “Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™).” PMID 28012176 ↗ Jan 2017 |
| Action | Inhibit | “intracellular inhibition of the cortisol-regenerating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)” PMID 28012176 ↗ Jan 2017 |
| Modality | Small molecule | “Medicinal chemistry optimization of a series of amido-thiophene analogues was performed to identify potent and selective 11β-HSD1 inhibitors with optimized oral...” PMID 28012176 ↗ Jan 2017 |
| Route | Oral | “Oral capsule” NCT01770886 ↗ |