Drugs / S241656
last change Apr 2023 re-read 2 minutes ago

S241656

targets BRAF, KRAS, NRAS via inhibition

Developed for
colorectal carcinoma · histiocytic and dendritic cell neoplasm · histiocytosis · metastatic malignant neoplasm in the brain · non-small cell lung carcinoma · thyroid gland carcinoma
Investigated by
Servier

Trials 1 · a red edge is where a trial was stopped

20242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/2 NCT05786924 Apr 2023 → Jun 2028 expected colorectal carcinoma, histiocytic and dendritic cell neoplasm, histiocytosis, metastatic malignant neoplasm in the brain +2 Servier Recruiting No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 1 source stands behind the page.

FieldValueCited text
Known as S241656 ClinicalTrials.gov intervention name — accepted as the source's own label NCT05786924
Action Inhibit “RAF inhibitor targeting all classes of oncogenic BRAF alterations (Classes I, II, and III) and constitutively active CRAF, KRAS or NRAS mutations” NCT05786924
Route Oral “All patients will self-administer S241656 orally in 28-day cycles until disease progression, toxicity, withdrawal of consent, or termination of the study” NCT05786924
Target BRAF “RAF inhibitor targeting all classes of oncogenic BRAF alterations (Classes I, II, and III) and constitutively active CRAF, KRAS or NRAS mutations” NCT05786924
Target KRAS “RAF inhibitor targeting all classes of oncogenic BRAF alterations (Classes I, II, and III) and constitutively active CRAF, KRAS or NRAS mutations” NCT05786924
Target NRAS “RAF inhibitor targeting all classes of oncogenic BRAF alterations (Classes I, II, and III) and constitutively active CRAF, KRAS or NRAS mutations” NCT05786924