Drugs / Brivudine
Brivudine
also known as
RP101 · 17β-oestradiol-3-phosphate · Brivudin · Brivudina · Bromovinyldeoxyuridine · BVDU · NSC-633770 · Zostex
Small molecule targets HSPB1 via inhibition
Trials 2 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 21 trial | ||||||
| Phase 2 | NCT03821415 | Jan → Nov 2019 | dry eye syndrome | Redwood Pharma AB | Completed | No outcome recorded |
| Phase 41 trial | ||||||
| Phase 4 | NCT07099157 | Aug 2025 → Dec 2026 expected | herpes zoster | Peking University Third Hospital | Recruiting | No outcome recorded |
Also used as a comparator or background therapy in 1 trial
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 2 | NCT00550004 Comparator | Sep 2007 → Aug 2009 | pancreatic adenocarcinoma | SciClone Pharmaceuticals | Terminated | No outcome recorded |
Evidence & citations 13 cited values
Every value below carries the sentence it was read from. 5 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Brivudine | “We reported earlier that RP101 (Bromovinyldeoxyuridine, BVDU, Brivudine) improves the efficacy of chemotherapy in pancreatic cancer.” PMID 21833720 ↗ Jul 2011 |
| Known as | 17β-oestradiol-3-phosphate | “Redwood Pharma is developing the novel ophthalmic product RP101 containing the known active substance 17β-oestradiol-3-phosphate and based upon the drug delivery platform...” NCT03821415 ↗ |
| Known as | Brivudin | ChEMBL registry synonym — accepted as the source's own label CHEMBL31634 ↗ |
| Known as | Brivudina | ChEMBL registry synonym — accepted as the source's own label CHEMBL31634 ↗ |
| Known as | Bromovinyldeoxyuridine | “We reported earlier that RP101 (Bromovinyldeoxyuridine, BVDU, Brivudine) improves the efficacy of chemotherapy in pancreatic cancer.” PMID 21833720 ↗ Jul 2011 |
| Known as | BVDU | “We reported earlier that RP101 (Bromovinyldeoxyuridine, BVDU, Brivudine) improves the efficacy of chemotherapy in pancreatic cancer.” PMID 21833720 ↗ Jul 2011 |
| Known as | NSC-633770 | ChEMBL registry synonym — accepted as the source's own label CHEMBL31634 ↗ |
| Known as | RP101 | “Redwood Pharma is developing the novel ophthalmic product RP101 containing the known active substance 17β-oestradiol-3-phosphate and based upon the drug delivery platform...” NCT03821415 ↗ |
| Known as | Zostex | ChEMBL registry synonym — accepted as the source's own label CHEMBL31634 ↗ |
| Action | Inhibit | “Here, we report that RP101 binds in vitro to the heat shock protein HSPB1 and inhibits interaction with its binding partners.” PMID 21833720 ↗ Jul 2011 |
| Modality | Small molecule | — CHEMBL31634 ↗ |
| Route | Oral | “190 mg oral tablet” NCT00550004 ↗ |
| Target | HSPB1 | “Here, we report that RP101 binds in vitro to the heat shock protein HSPB1 and inhibits interaction with its binding partners.” PMID 21833720 ↗ Jul 2011 |