INDINAVIR ANHYDROUS
Other / unclassified targets MMP2 via inhibition
Regulatory milestones approvals, filings & regulatory actions · 4 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Label expansions (2) | US (FDA) | CRIXIVAN | — | 1998-02-06 – 2000-10-23 | fda.gov ↗ |
| Approved | EU (EMA) | Crixivan | — | 1996-10-04 | europa.eu ↗ |
| Approved | US (FDA) | CRIXIVAN | — | 1996-03-13 | fda.gov ↗ |
Trials 81
News releases announcing trial results or a regulatory action · 1
| Date | Issuer | Release |
|---|---|---|
| 1998-09-23 | Gilead Sciences | Results Gilead Sciences Provides Update on PREVEON® Clinical Program for the Treatment of HIV gilead.com ↗
These data demonstrate that PREVEON has durable anti-HIV activity in treatment-experienced patients, including those infected with strains of HIV resistant to most currently approved therapies. |
All press releases naming this drug 1 release
| Date | Issuer | Release |
|---|---|---|
| 1998-09-23 | Gilead Sciences | Gilead Sciences Provides Update on PREVEON® Clinical Program for the Treatment of HIV gilead.com ↗ |
Evidence & citations 18 cited values
Every value below carries the sentence it was read from. 101 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | INDINAVIR ANHYDROUS | ChEMBL registry synonym — accepted as the source's own label CHEMBL115 ↗ |
| Known as | Crixivan | “100 patients will be randomized to receive Zerit (Stavudine) + Epivir (Lamivudine) + Crixivan (Indinavir) and 100 patients will be randomized to receive Retrovir (Zidovudine) +...” NCT00002369 ↗4“To evaluate the safety, tolerability, and plasma concentration profiles of indinavir sulfate ( MK-639; Crixivan ) in HIV-seropositive older children and adolescents.” NCT00002351 ↗ “Viracept (Nelfinavir Mesylate) 1250 Mg BID, Crixivan (Indinavir Sulfate) 1200mg q12h, and Sustiva (Efavirenz; DMP-266) 600 Mg q24h” NCT00002235 ↗ “Crixivan (indinavir) plus Lexiva (fosamprenavir)” NCT00148785 ↗ “indinavir sulfate ( MK-639; Crixivan )” NCT00002155 ↗ |
| Known as | IDV | “The purpose of this study was to compare the pharmacokinetics, safety, and tolerability of indinavir (IDV)/RTV at 800/200 mg (arm A) and 400/400 mg (arm B) administered twice...” PMID 15483465 ↗ Nov 200427“Adult AIDS Clinical Trials Group 5043 examined pharmacokinetic (PK) interactions between amprenavir (APV) and efavirenz (EFV) both by themselves and when nelfinavir (NFV),...” PMID 16048950 ↗ Aug 2005 “The purpose of this study is to see whether taking indinavir (IDV) plus ritonavir (RTV) plus stavudine (d4T) plus lamivudine (3TC) 2 times each day is safe and can lower the...” NCT00002241 ↗ “The purpose of this study is to see if it is safe and effective to give an anti-HIV drug combination of indinavir (IDV) plus stavudine (d4T) plus lamivudine (3TC) to...” NCT00000901 ↗ “This study will see how safe and effective against HIV the drugs L-756423 plus indinavir (IDV) are compared to just IDV when taken with stavudine (d4T) and lamivudine (3TC).” NCT00002424 ↗ “To compare the effects on CD4 counts and safety of MK-639 (indinavir, IDV) and AZT administered concomitantly to MK-639 alone and AZT alone in HIV-1 seropositive patients.” NCT00002443 ↗ “Patients receiving combination antiretroviral therapy with indinavir (IDV), zidovudine (ZDV)(or d4T) and lamivudine (3TC) show viral suppression for two years or more.” NCT00000916 ↗ “The purpose of this study is to see if it is safe and effective to treat HIV-infected patients with indinavir (IDV) plus nelfinavir (NFV), 2 anti-HIV medications.” NCT00002375 ↗ “All patients will receive open label induction therapy with zidovudine (ZDV), lamivudine (3TC) and indinavir (IDV) for 6 months.” NCT00001084 ↗ “The study-specified PIs will be indinavir (IDV), nelfinavir (NFV), or two PIs of patient and doctor choice.” NCT00000922 ↗ “The drugs to be used in combination with DLV are zidovudine (ZDV), indinavir (IDV), and lamivudine (3TC).” NCT00002401 ↗ |
| Known as | Indinavir | “Any approved antiretroviral protease inhibitor such as atazanavir, darunavir, indinavir, ritonavir, and saquinavir ; consistent with the most recent prescribing information documents” NCT02556268 ↗91“Tenofovir+Emtricitabine+Third agent (Including a ritonavir-boosted protease inhibitor : saquinavir or indinavir or fosamprenavir or tipranavir or darunavir or atazanavir or lopinavir” NCT02302547 ↗ “Indinavir” NCT02300623 ↗ |
| Known as | Indinavir monohydrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL115 ↗ |
| Known as | Indinavir Sulfate | “Viracept (Nelfinavir Mesylate) 1250 Mg BID, Crixivan (Indinavir Sulfate) 1200mg q12h, and Sustiva (Efavirenz; DMP-266) 600 Mg q24h” NCT00002235 ↗6“MK0639, indinavir sulfate / Duration of Treatment: 48 Weeks” NCT00541463 ↗ “indinavir sulfate (IDV)” NCT00039741 ↗ |
| Known as | Indinavir sulphate | ChEMBL registry synonym — accepted as the source's own label CHEMBL115 ↗ |
| Known as | Indinavir system suitability | ChEMBL registry synonym — accepted as the source's own label CHEMBL115 ↗ |
| Known as | indinavir/r | “The study-treatment were lopinavir/r 100/400mg bid or indinavir/r 100/400mg bid for PI-class, for NNRTI-class, efavirenz or nevirapine and all NRTIs except D4T and DDC at usual dosage.” NCT00122668 ↗ |
| Known as | Indinaviri sulfas | ChEMBL registry synonym — accepted as the source's own label CHEMBL115 ↗ |
| Known as | L-735,524 | ChEMBL registry synonym — accepted as the source's own label CHEMBL115 ↗ |
| Known as | MK-0639 | “MK0639, indinavir sulfate / Duration of Treatment: 48 Weeks” NCT00541463 ↗1“protease inhibitor indinavir (MK-0639)” NCT00001443 ↗ |
| Known as | MK-639 | “To compare the effects on CD4 counts and safety of MK-639 (indinavir, IDV) and AZT administered concomitantly to MK-639 alone and AZT alone in HIV-1 seropositive patients.” NCT00002443 ↗2“To evaluate the safety, tolerability, and plasma concentration profiles of indinavir sulfate ( MK-639; Crixivan ) in HIV-seropositive older children and adolescents.” NCT00002351 ↗ “indinavir sulfate ( MK-639; Crixivan )” NCT00002155 ↗ |
| Known as | NSC-697197 | ChEMBL registry synonym — accepted as the source's own label CHEMBL115 ↗ |
| Action | Inhibit | “which is an inhibitor of the HIV protease enzyme” NCT00000804 ↗ |
| Modality | Other / unclassified | “Protease Inhibitor” NCT00000919 ↗ |
| Route | Oral | “their oral administration is staggered” NCT00000877 ↗ |
| Target | MMP2 | “through a blockade of matrix metalloprotease 2 (MMP2) proteolytic activation.” NCT00362310 ↗ |