Drugs / OT-101
last change Jun 2026 re-read 3 minutes ago

OT-101

Antisense oligonucleotide targets TGFB2

Developed for
COVID-19 · malignant pleural mesothelioma · pancreatic ductal adenocarcinoma
Investigated by
Oncotelic Inc.

Trials 2

20222023202420252026202720282029
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 22 trials
Phase 2 NCT05425576 Jun 2025 → Dec 2028 expected malignant pleural mesothelioma Oncotelic Inc. Not yet recruiting No outcome recorded
Phase 2 NCT04801017 Apr → Aug 2021 COVID-19 Oncotelic Inc. Unknown No outcome recorded
Comparator or background therapy1 trial
Phase 2/3 NCT06079346 Comparator May 2024 → Jun 2026 overdue pancreatic ductal adenocarcinoma Oncotelic Inc. Recruiting No outcome recorded

Press releases naming this drug 22 releases

DateIssuerRelease
2026-02-12 Mateon Therapeutics Oncotelic Therapeutics, Inc. and Sapu Bioscience Expand International IP Coverage for OT-101, Strengthening CNS and Neurology Commercialization Pathway oncotelic.com ↗
2025-03-25 Mateon Therapeutics Oncotelic Therapeutics Announces Successful Completion of Phase 1 Trial of OT-101 and IL-2, Highlights Findings at SWCR 2025 Conference oncotelic.com ↗
2023-08-23 Mateon Therapeutics Sapu BioScience and Cromos Pharma initiating P201 - A Registrational trial for OT-101 in Pancreatic Cancer oncotelic.com ↗
2023-01-25 Mateon Therapeutics Oncotelic Initiates Clinical Trials Evaluating OT-101 against Metastatic Pancreatic Cancer oncotelic.com ↗
2022-11-08 Mateon Therapeutics Oncotelic Initiates Clinical Trials Evaluating OT-101 against Pediatric Gliomas oncotelic.com ↗
2022-10-12 Mateon Therapeutics Oncotelic Awarded BARDA Funding for Development of OT-101 for long COVID oncotelic.com ↗
2022-07-12 Mateon Therapeutics Oncotelic Announces Presentation of P001- OT-101 Phase 1/2 Trial in Pancreatic Cancer oncotelic.com ↗
2022-06-15 Mateon Therapeutics Oncotelic Provides Update on OT-101 at the 2022 BIO International Convention oncotelic.com ↗
2022-05-25 Mateon Therapeutics Oncotelic Therapeutics Receives FDA Clearance for Phase 2 Clinical Trial of OT-101/Pembroluzimab Combination for Mesothelioma (M201) oncotelic.com ↗
2021-12-01 Mateon Therapeutics Oncotelic Initiates Phase 2 Trial Evaluating OT-101 in Combination with KEYTRUDA® for Mesothelioma oncotelic.com ↗
2021-11-23 Mateon Therapeutics ONCOTELIC ANNOUNCES POSITIVE TOPLINE DATA FOR OT-101 C001 COVID STUDY oncotelic.com ↗
2021-11-16 Mateon Therapeutics Oncotelic Announces Successful Completion of the Safety Evaluation of a TGF-β Inhibitor (OT-101) and IL-2 (Aldesleukin) in Phase 1 Combination Trial in Solid Tumor Cancers oncotelic.com ↗

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 3 sources stand behind the page.

FieldValueCited text
Known as OT-101 ClinicalTrials.gov intervention name — accepted as the source's own label NCT04801017 ↗
2

NCT06079346 ↗

NCT05425576 ↗

Action Inhibit “OT-101, a TGF-b2 inhibitor” NCT05425576 ↗
Modality Antisense oligonucleotide “TGF β2 specific synthetic 18 mer phosphorothioate antisense oligodeoxynucleotide” NCT04801017 ↗
Route Intravenous “140 mg/m2 daily intravenous (i.v.) infusion for 7 continuous days.” NCT04801017 ↗
Target TGFB2 “TGF β2 specific synthetic 18 mer phosphorothioate antisense oligodeoxynucleotide” NCT04801017 ↗