Drugs / RISOVALISIB
last change Feb 2026 re-read 2 minutes ago

RISOVALISIB

also known as CYH33

Small molecule

Developed for
breast cancer · ovarian cancer · cancer · endometrial cancer · PIK3CA-related overgrowth spectrum · prostate cancer · vascular malformation
Investigated by
Haihe Biopharma Co., Ltd.

Trials 5 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT04856371 Apr 2021 → Mar 2022 breast cancer Haihe Biopharma Co., Ltd. Unknown No outcome recorded
Phase 1 NCT04586335 Sep 2020 → Feb 2023 breast cancer, endometrial cancer, ovarian cancer, prostate cancer Haihe Biopharma Co., Ltd. Terminated No outcome recorded
Phase 1 NCT03544905 Jul 2018 → Dec 2024 cancer Haihe Biopharma Co., Ltd. Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT06975618 Aug 2023 → Dec 2029 expected PIK3CA-related overgrowth spectrum, vascular malformation Haihe Biopharma Co., Ltd. Recruiting No outcome recorded
Phase 21 trial
Phase 2 NCT05043922 Oct 2021 → Jul 2024 overdue ovarian cancer Haihe Biopharma Co., Ltd. Active not recruiting No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

FieldValueCited text
Known as RISOVALISIB ChEMBL registry synonym — accepted as the source's own label CHEMBL4800252
Known as CYH33 ClinicalTrials.gov intervention name — accepted as the source's own label NCT03544905
4

NCT04586335

NCT05043922

NCT04856371

NCT06975618

Action Inhibit “CYH33 is a novel, highly potent and selective inhibitor of phosphatidylinositol 3-kinase α” NCT04586335
Modality Small molecule CHEMBL4800252
Route Oral “CYH33, an Oral α-specific PI3K Inhibitor” NCT04586335