Drugs / Anacetrapib
last change Nov 2018 re-read 2 minutes ago

Anacetrapib

also known as MK-0859 · ANA

Small molecule targets CETP via inhibition

Developed for
hyperlipidemia · familial hypercholesterolemia · atherosclerotic cardiovascular disease · coronary artery disorder · homozygous familial hypercholesterolemia
Investigated by
Merck Sharp & Dohme LLC · University of Oxford

Trials 15 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 15 trials
Phase 1 NCT01122667 Jun 2010 → Jun 2011 hyperlipidemia Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT01114490 May → Jul 2010 hyperlipidemia Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT00990808 Nov 2009 → Jun 2011 hyperlipidemia Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT00565006 Jul → Sep 2006 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT00565292 Jul → Aug 2006 hyperlipidemia Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 22 trials
Phase 2 NCT00977288 Sep 2009 → Mar 2010 hyperlipidemia Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 2 NCT00325455 Jun 2006 → Feb 2007 hyperlipidemia Merck Sharp & Dohme LLC Terminated No outcome recorded
Phase 38 trials
Phase 3 NCT01841684 Jun 2013 → Jun 2014 homozygous familial hypercholesterolemia Merck Sharp & Dohme LLC Terminated No outcome recorded
Phase 3 NCT01860729 May 2013 → May 2015 hyperlipidemia Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT01824238 May 2013 → May 2014 familial hypercholesterolemia Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT01760460 Mar 2013 → Mar 2015 hyperlipidemia Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT01717300 Nov 2012 → Oct 2014 hyperlipidemia Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT01524289 Feb 2012 → Feb 2014 familial hypercholesterolemia Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT01252953 Jun 2011 → Jan 2017 overdue atherosclerotic cardiovascular disease University of Oxford Active not recruiting No outcome recorded
Phase 3 NCT00685776 Mar 2008 → Jul 2009 coronary artery disorder Merck Sharp & Dohme LLC Completed No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 20 sources stand behind the page.

FieldValueCited text
Known as anacetrapib Anacetrapib (MK-0859) is a CETP inhibitor currently under development.” PMID 18068514 Dec 2007
12

NCT00685776

NCT01252953

NCT01122667

NCT01524289

NCT01717300

NCT01841684

NCT01114490

NCT01824238

NCT00990808

NCT01860729

NCT00977288

NCT01760460

Known as ANA “We investigated the effects of the cholesteryl ester (CE) transfer protein inhibitor anacetrapib (ANA) on plasma lipids, lipoprotein subfraction concentrations, and lipoprotein...” PMID 22180633 Dec 2011
1

“This study evaluated the effects of anacetrapib (ANA) on lipids and safety when administered as monotherapy or in combination with atorvastatin (ATV) in Japanese patients...” PMID 23958252 Jun 2013

Known as MK-0859 “Anacetrapib (MK-0859) is a CETP inhibitor currently under development.” PMID 18068514 Dec 2007
4

“single dose administration of anacetrapib (MK0859) 100 mg oral tablet” NCT01114490

“single dose administration of anacetrapib (MK0859) 100 mg oral tablet” NCT01122667

“transfer protein inhibitor anacetrapib (MK-0859) in patients” PMID 21982664 Sep 2011

NCT00325455

Action Inhibit “Anacetrapib is a cholesteryl ester transfer protein (CETP) inhibitor” PMID 24737712 Apr 2014
Modality Small molecule CHEMBL1800807
Route Oral “received anacetrapib doses of 0, 10, 40, 150, or 300 mg orally once a day with a meal for 28 days.” PMID 18068514 Dec 2007
Target CETP “anacetrapib, a CETP (cholesteryl ester transfer protein) inhibitor” PMID 28729361 Jul 2017