Drugs / Alverine
Alverine
also known as
alverine citrate · Alverina · Antispasmin · Audmonal · Calmabel · Gamatran citrate · Gielism · NSC-35459 · +11 more
Small molecule targets HNF4A, HTR1A via activation / inhibition
Trials 7
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 21 trial | ||||||
| Phase 2 | NCT05508633 | Oct 2022 → Dec 2025 overdue | portal hypertension | Shanghai Changzheng Hospital | Enrolling by invitation | No outcome recorded |
| Phase 2/33 trials | ||||||
| Phase 2/3 | NCT06696248 | Nov 2024 → Sep 2025 overdue | portal hypertension | Shanghai Changzheng Hospital | Not yet recruiting | No outcome recorded |
| Phase 2/3 | NCT06470386 | Jun 2024 → Nov 2025 | portal hypertension | Shanghai Changzheng Hospital | Unknown | No outcome recorded |
| Phase 2/3 | NCT06473493 | Jun 2024 → Mar 2025 | portal hypertension | Shanghai Changzheng Hospital | Unknown | No outcome recorded |
| Phase 43 trials · 1 met primary | ||||||
| Phase 4 | NCT04145856 | Sep 2018 → May 2019 | irritable bowel syndrome | Hospital Juarez de Mexico | Completed | No outcome recorded |
| Phase 4 | NCT01404923 | Dec 2009 → Oct 2011 | irritable bowel syndrome | Laboratoires Mayoly Spindler | Completed | Met primary |
| Phase 4 | NCT00542295 | Jul 2007 → Jul 2008 | irritable bowel syndrome | Laboratoires Mayoly Spindler | Completed | No outcome recorded |
| Comparator or background therapy1 trial | ||||||
| — | NCT05100719 Comparator | Sep 2022 → Sep 2026 overdue | irritable bowel syndrome, lactose intolerance | University of Pecs | Not yet recruiting | No outcome recorded |
Evidence & citations 26 cited values
Every value below carries the sentence it was read from. 9 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Alverine | ClinicalTrials.gov intervention name — accepted as the source's own label NCT04145856 ↗ |
| Known as | Alverina | ChEMBL registry synonym — accepted as the source's own label CHEMBL253371 ↗ |
| Known as | alverine citrate | “On the basis of maintaining unchanged routine hepatoprotective and symptomatic supportive treatments and the original dose of carvedilol, participants will be administered with...” NCT06696248 ↗4“Antispasmodic/antifoam drug, consisting of Alverine Citrate 60 mg and Simethicone 300 mg, thrice daily (t.i.d)” NCT04145856 ↗ |
| Known as | Antispasmin | ChEMBL registry synonym — accepted as the source's own label CHEMBL253371 ↗ |
| Known as | Audmonal | ChEMBL registry synonym — accepted as the source's own label CHEMBL253371 ↗ |
| Known as | Calmabel | ChEMBL registry synonym — accepted as the source's own label CHEMBL253371 ↗ |
| Known as | Gamatran citrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL253371 ↗ |
| Known as | Gielism | ChEMBL registry synonym — accepted as the source's own label CHEMBL253371 ↗ |
| Known as | NSC-35459 | ChEMBL registry synonym — accepted as the source's own label CHEMBL253371 ↗ |
| Known as | Phenpropamine | ChEMBL registry synonym — accepted as the source's own label CHEMBL253371 ↗ |
| Known as | Phenpropamine citrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL253371 ↗ |
| Known as | Profenil citrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL253371 ↗ |
| Known as | Profenine | ChEMBL registry synonym — accepted as the source's own label CHEMBL253371 ↗ |
| Known as | Prophelan | ChEMBL registry synonym — accepted as the source's own label CHEMBL253371 ↗ |
| Known as | Proverine | ChEMBL registry synonym — accepted as the source's own label CHEMBL253371 ↗ |
| Known as | Relaxyl | ChEMBL registry synonym — accepted as the source's own label CHEMBL253371 ↗ |
| Known as | Spacolin | ChEMBL registry synonym — accepted as the source's own label CHEMBL253371 ↗ |
| Known as | Spasmaverine | ChEMBL registry synonym — accepted as the source's own label CHEMBL253371 ↗ |
| Known as | Spasmonal | ChEMBL registry synonym — accepted as the source's own label CHEMBL253371 ↗ |
| Known as | Spasmonal fte | ChEMBL registry synonym — accepted as the source's own label CHEMBL253371 ↗ |
| Action | Activate | “Hepatocyte nuclear factor 4-alpha activator” CHEMBL253371 ↗ |
| Action | Inhibit | “selectively antagonizing HTR1A” NCT05508633 ↗ |
| Modality | Small molecule | — CHEMBL253371 ↗ |
| Route | Oral | “The drug is orally given” NCT05508633 ↗ |
| Target | HNF4A | “Hepatocyte nuclear factor 4-alpha activator” CHEMBL253371 ↗ |
| Target | HTR1A | “selectively antagonizing HTR1A” NCT05508633 ↗ |